Conservation, Evolutionary: Difference between revisions

From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs)
INTREPID: polishing
Eric Martz (talk | contribs)
Line 142: Line 142:


==The ConSurf-DB Mechanism==
==The ConSurf-DB Mechanism==
The ConSurf DataBase server, [http://consurfdb.tau.ac.il ConSurf-DB]<ref name="consurfdb">PMID: 18971256</ref>, pre-calculates conservation levels for each amino acid in every protein chain in the [[Protein Data Bank]]. It went into service in 2008. It uses state-of-the-art methods, all published in peer-reviewed journals<ref name="consurfdb" />. Each protein chain is processed as follows.
Because results from the ConSurf DataBase server, [http://consurfdb.tau.ac.il ConSurf-DB]<ref name="consurfdb">PMID: 18971256</ref> are displayed within Proteopedia as ''Evolutionary Conservation'', an overview of its methods is provided here. ConSurf-DB pre-calculates conservation levels for each amino acid in every protein chain in the [[Protein Data Bank]]. It went into service in 2008. It uses state-of-the-art methods, all published in peer-reviewed journals<ref name="consurfdb" />. Each protein chain is processed as follows.


===ConSurf-DB Process===
===ConSurf-DB Process===