1ihm: Difference between revisions

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[[Image:1ihm.gif|left|200px]]<br /><applet load="1ihm" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1ihm.gif|left|200px]]<br /><applet load="1ihm" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ihm, resolution 3.4Å" />

'''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''<br />

==Overview==

Norwalk virus, a noncultivatable human calicivirus, is the major cause of, epidemic gastroenteritis in humans. The first x-ray structure of a, calicivirus capsid, which consists of 180 copies of a single protein, has, been determined by phase extension from a low-resolution electron, microscopy structure. The capsid protein has a protruding (P) domain, connected by a flexible hinge to a shell (S) domain that has a classical, eight-stranded beta-sandwich motif. The structure of the P domain is, unlike that of any other viral protein with a subdomain exhibiting a fold, similar to that of the second domain in the eukaryotic translation, elongation factor-Tu. This subdomain, located at the exterior of the, capsid, has the largest sequence variation among Norwalk-like human, caliciviruses and is likely to contain the determinants of strain, specificity and cell binding.

Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.

==About this Structure==

1IHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].

1IHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].

==Reference==

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[[Category: Bella, J.]]

[[Category: Dokland, T.]]

[[Category: Estes, M.K.]]

[[Category: Estes, M K.]]

[[Category: Hardy, M.E.]]

[[Category: Hardy, M E.]]

[[Category: Prasad, B.V.]]

[[Category: Prasad, B V.]]

[[Category: Rossmann, M.G.]]

[[Category: Rossmann, M G.]]

[[Category: beta-barrel]]

[[Category: ef-tu-like domain caliciviridae]]

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[[Category: t=3 icosahedral capsid]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:58 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1ihm.gif|left|200px]]<br /><applet load="1ihm" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ihm.gif|left|200px]]<br /><applet load="1ihm" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ihm, resolution 3.4&Aring;" />
 '''CRYSTAL STRUCTURE ANALYSIS OF NORWALK VIRUS CAPSID'''<br />
 ==Overview==
-Norwalk virus, a noncultivatable human calicivirus, is the major cause of, epidemic gastroenteritis in humans. The first x-ray structure of a, calicivirus capsid, which consists of 180 copies of a single protein, has, been determined by phase extension from a low-resolution electron, microscopy structure. The capsid protein has a protruding (P) domain, connected by a flexible hinge to a shell (S) domain that has a classical, eight-stranded beta-sandwich motif. The structure of the P domain is, unlike that of any other viral protein with a subdomain exhibiting a fold, similar to that of the second domain in the eukaryotic translation, elongation factor-Tu. This subdomain, located at the exterior of the, capsid, has the largest sequence variation among Norwalk-like human, caliciviruses and is likely to contain the determinants of strain, specificity and cell binding.
+Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of 180 copies of a single protein, has been determined by phase extension from a low-resolution electron microscopy structure. The capsid protein has a protruding (P) domain connected by a flexible hinge to a shell (S) domain that has a classical eight-stranded beta-sandwich motif. The structure of the P domain is unlike that of any other viral protein with a subdomain exhibiting a fold similar to that of the second domain in the eukaryotic translation elongation factor-Tu. This subdomain, located at the exterior of the capsid, has the largest sequence variation among Norwalk-like human caliciviruses and is likely to contain the determinants of strain specificity and cell binding.
 ==About this Structure==
-IHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].
+IHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Norwalk_virus Norwalk virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IHM OCA].
 ==Reference==
@@ Line 15: / Line 15: @@
 [[Category: Bella, J.]]
 [[Category: Dokland, T.]]
-[[Category: Estes, M.K.]]
+[[Category: Estes, M K.]]
-[[Category: Hardy, M.E.]]
+[[Category: Hardy, M E.]]
-[[Category: Prasad, B.V.]]
+[[Category: Prasad, B V.]]
-[[Category: Rossmann, M.G.]]
+[[Category: Rossmann, M G.]]
 [[Category: beta-barrel]]
 [[Category: ef-tu-like domain caliciviridae]]
@@ Line 24: / Line 24: @@
 [[Category: t=3 icosahedral capsid]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:02:09 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:11:58 2008''