Epitopes: Difference between revisions
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==Terminology== | ==Terminology== | ||
Antibody epitopes may also be called ''determinants'', which is an historically earlier but equally good term. The term ''epitope'' implies that the determinant is on the surface of the antigen ("epi"). It is unfortunate that ''epitope'' has caught on as the term to describe the peptide fragments that T cells recognize, since these are not necessarily derived from the surfaces of protein antigens, but may be derived from portions that were buried in the folded protein. | ===Antibody Epitopes=== | ||
Antibody epitopes may also be called ''determinants'', which is an historically earlier but equally good term. The term ''epitope'' implies that the determinant is on the surface of the antigen ("epi"). | |||
===T Lymphocyte Epitopes=== | |||
It is unfortunate that ''epitope'' has caught on as the term to describe the peptide fragments that T cells recognize, since these are not necessarily derived from the surfaces of protein antigens, but may be derived from portions that were buried in the folded protein. While the perhaps better terms ''cryptotope'' and ''unfoldon'' are never used, they illustrate the point. | |||
==References and Notes== | |||
<references /> | |||
