Sandbox 12345: Difference between revisions
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In the crystal structure of Torpedo californica [[acetylcholinesterase]] | In the crystal structure of Torpedo californica [[acetylcholinesterase]] | ||
(TcAChE) complexed with tacrine (THA), THA's acridine ring is stacked | (TcAChE) complexed with tacrine (THA), THA's acridine ring is stacked | ||
between the aromatic rings of W84 and F330, near the catalytic triad | between the aromatic rings of <scene name='Sandbox_12345/1acj_x/1'>W84 and F330</scene>, near the catalytic triad | ||
of AChE's active site which consists of S200, E327, H440. When | of AChE's active site which consists of S200, E327, H440. When | ||
comparing 3 recent complexes of TcAChE, i.e. edrophonium (EDR), | comparing 3 recent complexes of TcAChE, i.e. edrophonium (EDR), | ||
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provide complementary evidence assigning W84 and F330 to the "anionic" | provide complementary evidence assigning W84 and F330 to the "anionic" | ||
subsite of the active site and W279 to the "peripheral" anionic site. | subsite of the active site and W279 to the "peripheral" anionic site. | ||
<references/> | <references/> | ||
