2wf0: Difference between revisions

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{{Seed}}
[[Image:2wf0.png|left|200px]]
[[Image:2wf0.png|left|200px]]


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{{STRUCTURE_2wf0|  PDB=2wf0  |  SCENE=  }}  
{{STRUCTURE_2wf0|  PDB=2wf0  |  SCENE=  }}  


===HUMAN BACE-1 IN COMPLEX WITH 4-ETHYL-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-8-(2-OXO-1-PYRROLIDINYL)-6-QUINOLINECARBOXAMIDE===
===HUMAN BACE-1 IN COMPLEX WITH 4-ETHYL-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-8-(2-OXO-1-PYRROLIDINYL)-6-QUINOLINECARBOXAMIDE===


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{{ABSTRACT_PUBMED_19428244}}
{{ABSTRACT_PUBMED_19428244}}


==About this Structure==
==About this Structure==
2WF0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF0 OCA].  
[[2wf0]] is a 1 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF0 OCA].  
 
==See Also==
*[[Beta secretase|Beta secretase]]


==Reference==
==Reference==
<ref group="xtra">PMID:19428244</ref><references group="xtra"/>
<ref group="xtra">PMID:019428244</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
Line 50: Line 41:
[[Category: Walter, D S.]]
[[Category: Walter, D S.]]
[[Category: Wayne, G.]]
[[Category: Wayne, G.]]
[[Category: Alternative splicing]]
[[Category: Asp-2]]
[[Category: Asp-2]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
Line 61: Line 51:
[[Category: Memapsin-2]]
[[Category: Memapsin-2]]
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 24 20:33:43 2009''

Revision as of 13:26, 27 July 2012

File:2wf0.png

Template:STRUCTURE 2wf0

HUMAN BACE-1 IN COMPLEX WITH 4-ETHYL-N-((1S,2R)-2-HYDROXY-1-(PHENYLMETHYL)-3-(((3-(TRIFLUOROMETHYL)PHENYL)METHYL)AMINO) PROPYL)-8-(2-OXO-1-PYRROLIDINYL)-6-QUINOLINECARBOXAMIDE

Template:ABSTRACT PUBMED 19428244

About this Structure

2wf0 is a 1 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Charrier N, Clarke B, Cutler L, Demont E, Dingwall C, Dunsdon R, Hawkins J, Howes C, Hubbard J, Hussain I, Maile G, Matico R, Mosley J, Naylor A, O'Brien A, Redshaw S, Rowland P, Soleil V, Smith KJ, Sweitzer S, Theobald P, Vesey D, Walter DS, Wayne G. Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3664-8. Epub 2009 Apr 17. PMID:19428244 doi:10.1016/j.bmcl.2009.03.165

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