3e2t: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 23: | Line 23: | ||
[[Image:3e2t_Trp_interactions.png| 500px]] | [[Image:3e2t_Trp_interactions.png| 500px]] | ||
<br/> | <br/> | ||
The substrate specificity of TPH1 has been studied previously. These studies have shown that the substrate specificity i mainly controlled by Tyr236 <ref>PMID: 10993738</ref> and Phe314<ref>PMID: 11747434</ref> <ref>PMID: 11922614</ref>. Tyr236 is also involved in the binding of the tetrahydrobiopterin as seen in the structure of human TPH1 ([[1mlw]]). | The substrate specificity of TPH1 has been studied previously. These studies have shown that the substrate specificity i mainly controlled by Tyr236 <ref>PMID: 10993738</ref> and Phe314<ref>PMID: 11747434</ref> <ref>PMID: 11922614</ref>. Tyr236 is also involved in the binding of the tetrahydrobiopterin as seen in the structure of human TPH1 ([[1mlw]]) and in the binding of tryptophan, as seen in this structure. Phe314 is a smaller amino acid than the corresponding tryptophan seen in TH and PAH. Phenylalanine instead of tryptophan at position 314 results in a larger binding cavity in TPH with room for the tryptophan substrate. | ||
| Line 57: | Line 57: | ||
<ref group="xtra">PMID:18937498</ref><references group="xtra"/> | <ref group="xtra">PMID:18937498</ref><references group="xtra"/> | ||
<ref group="xtra">PMID: 18055219</ref><references group="xtra"/> | <ref group="xtra">PMID: 18055219</ref><references group="xtra"/> | ||
<references/> | |||
[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Tryptophan 5-monooxygenase]] | [[Category: Tryptophan 5-monooxygenase]] | ||
