C-Myc: Difference between revisions
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<applet load='2a93' size='300' frame='true' align='right' caption='c-Myc is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'/> | |||
== Overview == | |||
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The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. | The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. | ||
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | ||
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Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179. | Ohtsuki, Nishitani, Hatamochi, Yawata, & Namba (1991) Analysis of methylation in the c-Myc gene in five human myeloma cell lines. British Journal of Haematology. 77: 172-179. | ||
Takahashi et al., (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell. 131: 1-12. | |||
