Sandbox Z-DNA: Difference between revisions
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== Structure == | == Structure == | ||
<applet load='2acj' size='280' frame='true' align='left' caption=' B-Z DNA ' scene ='Sandbox_Z-DNA/B-z/7' /> | <applet load='2acj' size='280' frame='true' align='left' caption=' B-Z DNA ' scene ='Sandbox_Z-DNA/B-z/7' /> | ||
Z-DNA <scene name='Sandbox_Z-DNA/B-z/7'>(default scene)</scene> can form ''invitro'' from B-DNA by raising negative super helical stress or under low salt conditions when deoxycytosine is 5-methylated. The formation of Z-DNA ''invivo'' is an energy requiring process. it forms behind a moving RNA polymerase when it moves through DNA double helix during transcription and is subsequently stabilized due to the generation of negative supercoils. Z-DNA is the first single crystal X-ray structure of a DNA fragment. It was crystallized as a self complementary DNA hexamer d(CG)<sub>3</sub> by Andrew Wang, Alexander Rich and their co-workers at MIT in 1979. <ref name = 'Rich'>PMID:12838348</ref><ref name ='Wang'>PMID:17485386</ref> | Z-DNA <scene name='Sandbox_Z-DNA/B-z/7'>(default scene)</scene> can form ''invitro'' from B-DNA by raising negative super helical stress or under low salt conditions when deoxycytosine is 5-methylated. The formation of Z-DNA ''invivo'' is an energy requiring process. it forms behind a moving RNA polymerase when it moves through DNA double helix during transcription and is subsequently stabilized due to the generation of negative supercoils. Z-DNA is the first single crystal X-ray structure of a DNA fragment. It was crystallized as a self complementary DNA hexamer d(CG)<sub>3</sub> by Andrew Wang, Alexander Rich and their co-workers at MIT in 1979. <ref name = 'Rich'>PMID:12838348</ref><ref name ='Wang'>PMID:17485386</ref> | ||
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''Sources''<ref>PMID: 19417072</ref> | ''Sources''<ref>PMID: 19417072</ref> | ||
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