1sbu: Difference between revisions

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[[Image:1sbu.gif|left|200px]]<br /><applet load="1sbu" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1sbu.gif|left|200px]]<br /><applet load="1sbu" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1sbu" />

'''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2'''<br />

==Overview==

The delta-conotoxin EVIA from the Conus ermineus venom, a recently, characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond, associated with the triggering of its biological activity. In this paper, we use the pseudoproline concept to target the presumed bioactive cis, conformation. We report the design and the synthesis of loop 2 analogs, from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13, unit or the natural proline residue. NMR studies in water and molecular, modeling allowed us to identify the amide bond "locked" in a cis, conformation for as in the suggested bioactive form of the natural toxin.

The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.

==About this Structure==

1SBU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].

1SBU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].

==Reference==

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[[Category: vi beta turn]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 00~~:14:~~27 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:53 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1sbu.gif|left|200px]]<br /><applet load="1sbu" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1sbu.gif|left|200px]]<br /><applet load="1sbu" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1sbu" />
 '''NMR structure of a peptide containing a dimetylthiazolidine : an analog of delta conotoxin EVIA loop 2'''<br />
 ==Overview==
-The delta-conotoxin EVIA from the Conus ermineus venom, a recently, characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond, associated with the triggering of its biological activity. In this paper, we use the pseudoproline concept to target the presumed bioactive cis, conformation. We report the design and the synthesis of loop 2 analogs, from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13, unit or the natural proline residue. NMR studies in water and molecular, modeling allowed us to identify the amide bond "locked" in a cis, conformation for as in the suggested bioactive form of the natural toxin.
+The delta-conotoxin EVIA from the Conus ermineus venom, a recently characterized toxin, exhibits cis-trans isomerism of the Leu12-Pro13 bond associated with the triggering of its biological activity. In this paper we use the pseudoproline concept to target the presumed bioactive cis conformation. We report the design and the synthesis of loop 2 analogs from residue 8 to 18 containing either the cis-inducing Cys(PsiMe,MePro)13 unit or the natural proline residue. NMR studies in water and molecular modeling allowed us to identify the amide bond "locked" in a cis conformation for as in the suggested bioactive form of the natural toxin.
 ==About this Structure==
-SBU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].
+SBU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBU OCA].
 ==Reference==
@@ Line 22: / Line 22: @@
 [[Category: vi beta turn]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:14:27 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:53 2008''