3i6m: Difference between revisions

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'''Unreleased structure'''
{{Seed}}
[[Image:3i6m.jpg|left|200px]]


The entry 3i6m is ON HOLD until Paper Publication
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{{STRUCTURE_3i6m|  PDB=3i6m  |  SCENE=  }}


Authors: Lamba, D., Bartolucci, C.
===3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine===


Description: 3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  5 09:48:08 2009''
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==About this Structure==
3I6M is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I6M OCA].
 
==Reference==
<ref group="xtra">PMID:20025280</ref><ref group="xtra">PMID:15563167</ref><ref group="xtra">PMID:10606746</ref><ref group="xtra">PMID:11119642</ref><ref group="xtra">PMID:11449566</ref><ref group="xtra">PMID:12140604</ref><ref group="xtra">PMID:16711737</ref><references group="xtra"/>
[[Category: Acetylcholinesterase]]
[[Category: Torpedo californica]]
[[Category: Bartolucci, C.]]
[[Category: Lamba, D.]]
[[Category: Alternative splicing]]
[[Category: Alzheimer's disease]]
[[Category: Bis-functional galanthamine derivative]]
[[Category: Cell junction]]
[[Category: Cell membrane]]
[[Category: Cholinesterase]]
[[Category: Disulfide bond]]
[[Category: Glycoprotein]]
[[Category: Gpi-anchor]]
[[Category: Hydrolase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Neurotransmitter degradation]]
[[Category: Serine esterase]]
[[Category: Serine hydrolase]]
[[Category: Synapse]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 13:57:32 2010''

Revision as of 11:57, 13 January 2010

File:3i6m.jpg

Template:STRUCTURE 3i6m

3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine

Template:ABSTRACT PUBMED 20025280

About this Structure

3I6M is a 1 chain structure of sequence from Torpedo californica. Full crystallographic information is available from OCA.

Reference

  1. Bartolucci C, Haller LA, Jordis U, Fels G, Lamba D. Probing Torpedo californica Acetylcholinesterase Catalytic Gorge with Two Novel Bis-functional Galanthamine Derivatives. J Med Chem. 2009 Dec 21. PMID:20025280 doi:10.1021/jm901296p
  2. Greenblatt HM, Guillou C, Guenard D, Argaman A, Botti S, Badet B, Thal C, Silman I, Sussman JL. The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design. J Am Chem Soc. 2004 Dec 1;126(47):15405-11. PMID:15563167 doi:https://dx.doi.org/10.1021/ja0466154
  3. Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL. Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution. FEBS Lett. 1999 Dec 17;463(3):321-6. PMID:10606746
  4. Bartolucci C, Perola E, Pilger C, Fels G, Lamba D. Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs. Proteins. 2001 Feb 1;42(2):182-91. PMID:11119642
  5. Pilger C, Bartolucci C, Lamba D, Tropsha A, Fels G. Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking. J Mol Graph Model. 2001;19(3-4):288-96, 374-8. PMID:11449566
  6. Luttmann E, Linnemann E, Fels G. Galanthamine as bis-functional ligand for the acetylcholinesterase. J Mol Model. 2002 Jun;8(6):208-16. PMID:12140604 doi:10.1007/s00894-002-0086-9
  7. Alisaraie L, Haller LA, Fels G. A QXP-based multistep docking procedure for accurate prediction of protein-ligand complexes. J Chem Inf Model. 2006 May-Jun;46(3):1174-87. PMID:16711737 doi:10.1021/ci050343m

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