1wne: Difference between revisions

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[[Image:1wne.gif|left|200px]]<br /><applet load="1wne" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1wne.gif|left|200px]]<br /><applet load="1wne" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1wne, resolution 3.00Å" />

'''Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with a template-primer RNA'''<br />

==Overview==

Genome replication in picornaviruses is catalyzed by a virally encoded, RNA-dependent RNA polymerase, termed 3D. The enzyme performs this, operation, together with other viral and probably host proteins, in the, cytoplasm of their host cells. The crystal structure of the 3D polymerase, of foot-and-mouth disease virus, one of the most important animal, pathogens, has been determined unliganded and bound to a template-primer, RNA decanucleotide. The enzyme folds in the characteristic fingers, palm, and thumb subdomains, with the presence of an NH2-terminal segment that, encircles the active site. In the complex, several conserved amino acid, side chains bind to the template-primer, likely mediating the initiation, of RNA synthesis. The structure provides essential information for studies, on RNA replication and the design of antiviral compounds.

Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. The enzyme performs this operation, together with other viral and probably host proteins, in the cytoplasm of their host cells. The crystal structure of the 3D polymerase of foot-and-mouth disease virus, one of the most important animal pathogens, has been determined unliganded and bound to a template-primer RNA decanucleotide. The enzyme folds in the characteristic fingers, palm and thumb subdomains, with the presence of an NH2-terminal segment that encircles the active site. In the complex, several conserved amino acid side chains bind to the template-primer, likely mediating the initiation of RNA synthesis. The structure provides essential information for studies on RNA replication and the design of antiviral compounds.

==About this Structure==

1WNE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Foot_and_mouth_disease_virus Foot and mouth disease virus] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1WNE OCA].

1WNE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Foot_and_mouth_disease_virus Foot and mouth disease virus] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNE OCA].

==Reference==

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[[Category: rna-dependent rna polymerase]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 00~~:20:~~35 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:46:11 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1wne.gif|left|200px]]<br /><applet load="1wne" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1wne.gif|left|200px]]<br /><applet load="1wne" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1wne, resolution 3.00&Aring;" />
 '''Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with a template-primer RNA'''<br />
 ==Overview==
-Genome replication in picornaviruses is catalyzed by a virally encoded, RNA-dependent RNA polymerase, termed 3D. The enzyme performs this, operation, together with other viral and probably host proteins, in the, cytoplasm of their host cells. The crystal structure of the 3D polymerase, of foot-and-mouth disease virus, one of the most important animal, pathogens, has been determined unliganded and bound to a template-primer, RNA decanucleotide. The enzyme folds in the characteristic fingers, palm, and thumb subdomains, with the presence of an NH2-terminal segment that, encircles the active site. In the complex, several conserved amino acid, side chains bind to the template-primer, likely mediating the initiation, of RNA synthesis. The structure provides essential information for studies, on RNA replication and the design of antiviral compounds.
+Genome replication in picornaviruses is catalyzed by a virally encoded RNA-dependent RNA polymerase, termed 3D. The enzyme performs this operation, together with other viral and probably host proteins, in the cytoplasm of their host cells. The crystal structure of the 3D polymerase of foot-and-mouth disease virus, one of the most important animal pathogens, has been determined unliganded and bound to a template-primer RNA decanucleotide. The enzyme folds in the characteristic fingers, palm and thumb subdomains, with the presence of an NH2-terminal segment that encircles the active site. In the complex, several conserved amino acid side chains bind to the template-primer, likely mediating the initiation of RNA synthesis. The structure provides essential information for studies on RNA replication and the design of antiviral compounds.
 ==About this Structure==
-WNE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Foot_and_mouth_disease_virus Foot and mouth disease virus] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1WNE OCA].
+WNE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Foot_and_mouth_disease_virus Foot and mouth disease virus] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNE OCA].
 ==Reference==
@@ Line 25: / Line 25: @@
 [[Category: rna-dependent rna polymerase]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:20:35 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:46:11 2008''