1k3k: Difference between revisions
New page: left|200px<br /><applet load="1k3k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k3k" /> '''Solution Structure of a Bcl-2 Homolog from K... |
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'''Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus'''<br /> | '''Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus'''<br /> | ||
==Overview== | ==Overview== | ||
Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has | Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins. | ||
==About this Structure== | ==About this Structure== | ||
1K3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http:// | 1K3K is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K3K OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Fesik, S | [[Category: Fesik, S W.]] | ||
[[Category: Huang, Q.]] | [[Category: Huang, Q.]] | ||
[[Category: Olejniczak, E | [[Category: Olejniczak, E T.]] | ||
[[Category: Petros, A | [[Category: Petros, A M.]] | ||
[[Category: Virgin, H | [[Category: Virgin, H W.]] | ||
[[Category: bcl-2]] | [[Category: bcl-2]] | ||
[[Category: herpesvirus]] | [[Category: herpesvirus]] | ||
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[[Category: solution structure]] | [[Category: solution structure]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:29:45 2008'' | ||
Revision as of 11:29, 21 February 2008
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Solution Structure of a Bcl-2 Homolog from Kaposi's Sarcoma Virus
Overview
Kaposi sarcoma-associated herpes virus (KSHV) contains a gene that has functional and sequence homology to the apoptotic Bcl-2 family of proteins [Sarid, R., Sato, T., Bohenzky, R. A., Russo, J. J. & Chang, Y. (1997) Nat. Med. 3, 293-298]. The viral Bcl-2 protein promotes survival of infected cells and may contribute to the development of Kaposi sarcoma tumors [Boshoff, C. & Chang, Y. (2001) Annu. Rev. Med. 52, 453-470]. Here we describe the solution structure of the viral Bcl-2 homolog from KSHV. Comparison of the KSHV Bcl-2 structure to that of Bcl-2 and Bcl-x(L) shows that although the overall fold is the same, there are key differences in the lengths of the helices and loops. Binding studies on peptides derived from the Bcl-2 homology region 3 of proapoptotic family members indicate that the specificity of the viral protein is very different from what was previously observed for Bcl-x(L) and Bcl-2, suggesting that the viral protein has evolved to have a different mechanism of action than the host proteins.
About this Structure
1K3K is a Single protein structure of sequence from Human herpesvirus 4. Full crystallographic information is available from OCA.
Reference
Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus., Huang Q, Petros AM, Virgin HW, Fesik SW, Olejniczak ET, Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3428-33. PMID:11904405
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