1bwm: Difference between revisions

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[[Image:1bwm.gif|left|200px]]<br /><applet load="1bwm" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1bwm.gif|left|200px]]<br /><applet load="1bwm" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1bwm" />

'''A SINGLE-CHAIN T CELL RECEPTOR'''<br />

==Overview==

Using NMR spectroscopy, we determined the solution structure of a, single-chain T-cell receptor (scTCR) derived from the major, histocompatibility complex (MHC) class II-restricted D10 TCR. The, conformations of complementarity-determining regions (CDRs) 3beta and, 1alpha and surface properties of 2alpha are different from those of, related class I-restricted TCRs. We infer a conserved orientation for TCR, V(alpha) domains in complexes with both class I and II MHC-peptide, ligands, which implies that small structural variations in V(alpha) confer, MHC class preference. High mobility of CDR3 residues relative to other CDR, or framework residues (picosecond time scale) provides insight into immune, recognition and selection mechanisms.

Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.

==About this Structure==

1BWM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].

1BWM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].

==Reference==

Line 13:

[[Category: Mus musculus]]

[[Category: Single protein]]

[[Category: Hare, B.J.]]

[[Category: Hare, B J.]]

[[Category: Reinherz, E.L.]]

[[Category: Reinherz, E L.]]

[[Category: Wagner, G.]]

[[Category: Wyss, D.F.]]

[[Category: Wyss, D F.]]

[[Category: immunoglobulin]]

[[Category: immunoreceptor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 00~~:42:~~35 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:51 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1bwm.gif|left|200px]]<br /><applet load="1bwm" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1bwm.gif|left|200px]]<br /><applet load="1bwm" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1bwm" />
 '''A SINGLE-CHAIN T CELL RECEPTOR'''<br />
 ==Overview==
-Using NMR spectroscopy, we determined the solution structure of a, single-chain T-cell receptor (scTCR) derived from the major, histocompatibility complex (MHC) class II-restricted D10 TCR. The, conformations of complementarity-determining regions (CDRs) 3beta and, 1alpha and surface properties of 2alpha are different from those of, related class I-restricted TCRs. We infer a conserved orientation for TCR, V(alpha) domains in complexes with both class I and II MHC-peptide, ligands, which implies that small structural variations in V(alpha) confer, MHC class preference. High mobility of CDR3 residues relative to other CDR, or framework residues (picosecond time scale) provides insight into immune, recognition and selection mechanisms.
+Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.
 ==About this Structure==
-BWM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].
+BWM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BWM OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Mus musculus]]
 [[Category: Single protein]]
-[[Category: Hare, B.J.]]
+[[Category: Hare, B J.]]
-[[Category: Reinherz, E.L.]]
+[[Category: Reinherz, E L.]]
 [[Category: Wagner, G.]]
-[[Category: Wyss, D.F.]]
+[[Category: Wyss, D F.]]
 [[Category: immunoglobulin]]
 [[Category: immunoreceptor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:42:35 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:59:51 2008''