3e8n: Difference between revisions
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===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP=== | ===X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP=== | ||
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{{ABSTRACT_PUBMED_19706763}} | |||
==About this Structure== | ==About this Structure== | ||
3E8N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E8N OCA]. | 3E8N is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E8N OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:19706763</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mitogen-activated protein kinase kinase]] | [[Category: Mitogen-activated protein kinase kinase]] | ||
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[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:26:28 2009'' | ||
Revision as of 05:26, 16 September 2009
X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP
Template:ABSTRACT PUBMED 19706763
About this Structure
3E8N is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Iverson C, Larson G, Lai C, Yeh LT, Dadson C, Weingarten P, Appleby T, Vo T, Maderna A, Vernier JM, Hamatake R, Miner JN, Quart B. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47. Epub 2009 Aug 25. PMID:19706763 doi:10.1158/0008-5472.CAN-09-0679
Page seeded by OCA on Wed Sep 16 08:26:28 2009
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Mitogen-activated protein kinase kinase
- Wang, Z M.
- Yan, S.
- Acetylation
- Atp-binding
- Disease mutation
- Kinase
- Mek1
- Mek1-rdea119 complex
- Nucleotide-binding
- Phosphoprotein
- Protein kinase-ligand-mgatp complex
- Rdea-119
- Rdea119
- Serine/threonine-protein kinase
- Transferase
- Tyrosine-protein kinase
