1k8s: Difference between revisions

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[[Image:1k8s.gif|left|200px]]<br /><applet load="1k8s" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1k8s.gif|left|200px]]<br /><applet load="1k8s" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1k8s" />

'''BULGED ADENOSINE IN AN RNA DUPLEX'''<br />

==Overview==

Bulges are common structural motifs in RNA secondary structure and are, thought to play important roles in RNA-protein and RNA-drug interactions., Adenosine bases are the most commonly occurring unpaired base in double, helical RNA secondary structures. The solution conformation and dynamics, of a 25-nucleotide RNA duplex containing an unpaired adenosine, r(GGCAGAGUGCCGC): r(GCGGCACCUGCC) have been studied by NMR spectroscopy, and MORASS iterative relaxation matrix structural refinement. The results, show that the bulged adenosine residue stacks into the RNA duplex with, little perturbation around the bulged region. Most of the bases in the RNA, duplex adopt C(3)'-endo conformation, exhibiting the N-type sugar pucker, as found in the A form helices. The sugars of the bulged residue and the, 5' flanking residue to it are found to exhibit C(2)'-endo conformation., None of the residues are in syn conformation.

Bulges are common structural motifs in RNA secondary structure and are thought to play important roles in RNA-protein and RNA-drug interactions. Adenosine bases are the most commonly occurring unpaired base in double helical RNA secondary structures. The solution conformation and dynamics of a 25-nucleotide RNA duplex containing an unpaired adenosine, r(GGCAGAGUGCCGC): r(GCGGCACCUGCC) have been studied by NMR spectroscopy and MORASS iterative relaxation matrix structural refinement. The results show that the bulged adenosine residue stacks into the RNA duplex with little perturbation around the bulged region. Most of the bases in the RNA duplex adopt C(3)'-endo conformation, exhibiting the N-type sugar pucker as found in the A form helices. The sugars of the bulged residue and the 5' flanking residue to it are found to exhibit C(2)'-endo conformation. None of the residues are in syn conformation.

==About this Structure==

1K8S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1K8S OCA].

1K8S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8S OCA].

==Reference==

Solution conformation of a bulged adenosine base in an RNA duplex by relaxation matrix refinement., Thiviyanathan V, Guliaev AB, Leontis NB, Gorenstein DG, J Mol Biol. 2000 Jul 28;300(5):1143-54. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10903860 10903860]

[[Category: Protein complex]]

[[Category: Gorenstein, D.G.]]

[[Category: Gorenstein, D G.]]

[[Category: Guliaev, A.B.]]

[[Category: Guliaev, A B.]]

[[Category: Leontis, N.B.]]

[[Category: Leontis, N B.]]

[[Category: Thiviyanathan, V.]]

[[Category: bulged adenosine]]

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[[Category: rna bulges]]

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@@ Line 1: / Line 1: @@
-[[Image:1k8s.gif|left|200px]]<br /><applet load="1k8s" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1k8s.gif|left|200px]]<br /><applet load="1k8s" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1k8s" />
 '''BULGED ADENOSINE IN AN RNA DUPLEX'''<br />
 ==Overview==
-Bulges are common structural motifs in RNA secondary structure and are, thought to play important roles in RNA-protein and RNA-drug interactions., Adenosine bases are the most commonly occurring unpaired base in double, helical RNA secondary structures. The solution conformation and dynamics, of a 25-nucleotide RNA duplex containing an unpaired adenosine, r(GGCAGAGUGCCGC): r(GCGGCACCUGCC) have been studied by NMR spectroscopy, and MORASS iterative relaxation matrix structural refinement. The results, show that the bulged adenosine residue stacks into the RNA duplex with, little perturbation around the bulged region. Most of the bases in the RNA, duplex adopt C(3)'-endo conformation, exhibiting the N-type sugar pucker, as found in the A form helices. The sugars of the bulged residue and the, 5' flanking residue to it are found to exhibit C(2)'-endo conformation., None of the residues are in syn conformation.
+Bulges are common structural motifs in RNA secondary structure and are thought to play important roles in RNA-protein and RNA-drug interactions. Adenosine bases are the most commonly occurring unpaired base in double helical RNA secondary structures. The solution conformation and dynamics of a 25-nucleotide RNA duplex containing an unpaired adenosine, r(GGCAGAGUGCCGC): r(GCGGCACCUGCC) have been studied by NMR spectroscopy and MORASS iterative relaxation matrix structural refinement. The results show that the bulged adenosine residue stacks into the RNA duplex with little perturbation around the bulged region. Most of the bases in the RNA duplex adopt C(3)'-endo conformation, exhibiting the N-type sugar pucker as found in the A form helices. The sugars of the bulged residue and the 5' flanking residue to it are found to exhibit C(2)'-endo conformation. None of the residues are in syn conformation.
 ==About this Structure==
-K8S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K8S OCA].
+K8S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8S OCA].
 ==Reference==
 Solution conformation of a bulged adenosine base in an RNA duplex by relaxation matrix refinement., Thiviyanathan V, Guliaev AB, Leontis NB, Gorenstein DG, J Mol Biol. 2000 Jul 28;300(5):1143-54. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10903860 10903860]
 [[Category: Protein complex]]
-[[Category: Gorenstein, D.G.]]
+[[Category: Gorenstein, D G.]]
-[[Category: Guliaev, A.B.]]
+[[Category: Guliaev, A B.]]
-[[Category: Leontis, N.B.]]
+[[Category: Leontis, N B.]]
 [[Category: Thiviyanathan, V.]]
 [[Category: bulged adenosine]]
@@ Line 21: / Line 21: @@
 [[Category: rna bulges]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:56:54 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:31:20 2008''