1c4p: Difference between revisions

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[[Image:1c4p.gif|left|200px]]<br /><applet load="1c4p" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1c4p.gif|left|200px]]<br /><applet load="1c4p" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1c4p, resolution 2.4Å" />

'''BETA DOMAIN OF STREPTOKINASE'''<br />

==Overview==

Streptokinase, a 47 kDa secreted protein of hemolytic strains of, streptococci, is a human plasminogen activator and contains three, structural domains linked by flexible loops. We describe here the crystal, structure of the isolated streptokinase middle (SKbeta) domain determined, at 2.4 A resolution. Among the functionally important structural features, is a putative binding site for a kringle domain of plasminogen located at, the tip of a fully exposed hairpin loop. The distribution of genetically, conserved residues of SKbeta is strongly correlated with their functions., The extensive interface of the SKbeta dimer suggests that such dimers may, also exist in solution for free SKbeta.

Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.

==About this Structure==

1C4P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].

1C4P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].

==Reference==

Line 14:

[[Category: Streptococcus dysgalactiae subsp. equisimilis]]

[[Category: Wang, X.]]

[[Category: Zhang, X.C.]]

[[Category: Zhang, X C.]]

[[Category: plasminogen activator]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 25 01~~:06:~~12 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:02:22 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1c4p.gif|left|200px]]<br /><applet load="1c4p" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1c4p.gif|left|200px]]<br /><applet load="1c4p" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1c4p, resolution 2.4&Aring;" />
 '''BETA DOMAIN OF STREPTOKINASE'''<br />
 ==Overview==
-Streptokinase, a 47 kDa secreted protein of hemolytic strains of, streptococci, is a human plasminogen activator and contains three, structural domains linked by flexible loops. We describe here the crystal, structure of the isolated streptokinase middle (SKbeta) domain determined, at 2.4 A resolution. Among the functionally important structural features, is a putative binding site for a kringle domain of plasminogen located at, the tip of a fully exposed hairpin loop. The distribution of genetically, conserved residues of SKbeta is strongly correlated with their functions., The extensive interface of the SKbeta dimer suggests that such dimers may, also exist in solution for free SKbeta.
+Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.
 ==About this Structure==
-C4P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].
+C4P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Streptococcus dysgalactiae subsp. equisimilis]]
 [[Category: Wang, X.]]
-[[Category: Zhang, X.C.]]
+[[Category: Zhang, X C.]]
 [[Category: plasminogen activator]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:06:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:02:22 2008''