MDM2: Difference between revisions
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===MDM2 BOUND TO HUMAN P53 Protein=== | ===MDM2 BOUND TO HUMAN P53 Protein=== | ||
==About this Structure== | ==About this Structure== | ||
The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the <scene name='Matt_Routh_sandbox/Connection_to_p53/1'>109-residue</scene> | The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind the transactivation domain of p53 and downregulate its ability to activate transcription. In certain cancers, MDM2 amplification is a common event and contributes to the inactivation of p53. The crystal structure of the <scene name='Matt_Routh_sandbox/Connection_to_p53/1'>109-residue</scene> | ||
