Sandbox 43: Difference between revisions

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=='''Introduction to α-lactalbumin''' ==

α-lactalbumin is a 123 residue whey protein that is only found in milk and the mammary gland and is involved in production of lactose. α-lactalbumin is produced in the endoplasmic reticulum. When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis.<ref>Neville MC.. 2009. Introduction: alpha-lactalbumin, a multifunctional protein that specifies lactose synthesis in the Golgi. '' J Mammary Gland Biol Neoplasia.'' (3):211-2</ref> The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex.<ref name="ii">Cawthern KM, Permyakov E, Berliner LJ. 1996. Membrane-bound states of α-lactalbumin:Implications for the protein stability and conformation. Protein Science. 5: 1394-1405</ref> Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction:

α-lactalbumin is a 123 residue ~14kD whey protein that is only found in milk and the mammary gland and is involved in production of lactose. α-lactalbumin is produced in the endoplasmic reticulum. When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis.<ref>Neville MC.. 2009. Introduction: alpha-lactalbumin, a multifunctional protein that specifies lactose synthesis in the Golgi. '' J Mammary Gland Biol Neoplasia.'' (3):211-2</ref> The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex.<ref name="ii">Cawthern KM, Permyakov E, Berliner LJ. 1996. Membrane-bound states of α-lactalbumin:Implications for the protein stability and conformation. Protein Science. 5: 1394-1405</ref> Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction:

UDP-D-galactose + D-glucose -- lactose + UDP.<ref> Keith Brew, Thomas C. Vanaman and Robert L. Hill. 1967. The Role Of α-lactalbumin and The A Protein in Lactose Sythetase: A Unique Mechanism For the Control of A Biological Reaction. ''Biochemistry PNAS'' 491-497</ref>

Sandbox 43: Difference between revisions

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 {{template:Oberholser Sandbox Reservation}}
 =='''Introduction to α-lactalbumin''' ==
-α-lactalbumin is a 123 residue whey protein that is only found in milk and the mammary gland and is involved in production of lactose.  α-lactalbumin is produced in the endoplasmic reticulum.  When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis.<ref>Neville MC.. 2009. Introduction: alpha-lactalbumin, a multifunctional protein that specifies lactose synthesis in the Golgi. '' J Mammary Gland Biol Neoplasia.'' (3):211-2</ref> The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex.<ref name="ii">Cawthern KM, Permyakov E, Berliner LJ. 1996. Membrane-bound states of α-lactalbumin:Implications for the protein stability and conformation. Protein Science. 5: 1394-1405</ref> Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction:
+α-lactalbumin is a 123 residue ~14kD whey protein that is only found in milk and the mammary gland and is involved in production of lactose.  α-lactalbumin is produced in the endoplasmic reticulum.  When it makes it way to the Golgi it encounters galactosyltransferase and other substrates necessary for lactose synthesis.<ref>Neville MC.. 2009. Introduction: alpha-lactalbumin, a multifunctional protein that specifies lactose synthesis in the Golgi. '' J Mammary Gland Biol Neoplasia.'' (3):211-2</ref> The complex is made up of galactosyltransferase, α-lactalbumin, nucleotide substrate, and metal ion cofactors. α-lactalbumin is a modifier protein of the lactose synthetase complex.<ref name="ii">Cawthern KM, Permyakov E, Berliner LJ. 1996. Membrane-bound states of α-lactalbumin:Implications for the protein stability and conformation. Protein Science. 5: 1394-1405</ref> Lactose synthetase catalyzes the final step in the biosynthesis of lactose in the mammary gland by the reaction:
 UDP-D-galactose + D-glucose -- lactose + UDP.<ref> Keith Brew, Thomas C. Vanaman and Robert L. Hill. 1967. The Role Of α-lactalbumin and The A Protein in Lactose Sythetase:  A Unique Mechanism For the Control of A Biological Reaction. ''Biochemistry PNAS'' 491-497</ref>