3f66: Difference between revisions

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{{Seed}}
[[Image:3f66.png|left|200px]]
[[Image:3f66.png|left|200px]]


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{{STRUCTURE_3f66|  PDB=3f66  |  SCENE=  }}  
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===Human c-Met Kinase in complex with quinoxaline inhibitor===
===Human c-Met Kinase in complex with quinoxaline inhibitor===


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{{ABSTRACT_PUBMED_19059779}}
{{ABSTRACT_PUBMED_19059779}}
==Disease==
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Renal cell carcinoma, papillary, familial and sporadic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]], Autism, suseptibility to, 9 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164860 164860]]


==About this Structure==
==About this Structure==
3F66 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F66 OCA].  
[[3f66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F66 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19059779</ref><references group="xtra"/>
<ref group="xtra">PMID:019059779</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Receptor protein-tyrosine kinase]]
[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Tyrosine-protein kinase.]]
[[Category: Tyrosine-protein kinase.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 20:14:22 2009''

Revision as of 10:53, 13 February 2013

File:3f66.png

Template:STRUCTURE 3f66

Human c-Met Kinase in complex with quinoxaline inhibitor

Template:ABSTRACT PUBMED 19059779

About this Structure

3f66 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Porter J, Lumb S, Lecomte F, Reuberson J, Foley A, Calmiano M, le Riche K, Edwards H, Delgado J, Franklin RJ, Gascon-Simorte JM, Maloney A, Meier C, Batchelor M. Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):397-400. Epub 2008 Nov 21. PMID:19059779 doi:10.1016/j.bmcl.2008.11.062

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