MDM2: Difference between revisions
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. | ||
==Role in Cancer== | ==Role in Cancer== | ||
MDM2 is an active inhibitor of the p53 anti-tumorgenesis protein. When MDM2 is atached p53 is unable to release transcription factors that code for apoptosis or halting of the cell cycle. The full cell signaling pathway is very complex, but MDM2 is usually activated by | MDM2 is an active inhibitor of the p53 anti-tumorgenesis protein. When MDM2 is atached p53 is unable to release transcription factors that code for apoptosis or halting of the cell cycle. The full cell signaling pathway is very complex, but MDM2 is usually activated by | ||
