3h1v: Difference between revisions
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{{STRUCTURE_3h1v| PDB=3h1v | SCENE= }} | |||
===Human glucokinase in complex with a synthetic activator=== | |||
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{{ABSTRACT_PUBMED_19736020}} | |||
==Disease== | |||
Known disease associated with this structure: Diabetes mellitus, gestational OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], Diabetes mellitus, noninsulin-dependent, late onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], Diabetes mellitus, permanent neonatal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], Hyperinsulinemic hypoglycemia, familial, 3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]], MODY, type II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=138079 138079]] | |||
==About this Structure== | |||
3H1V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H1V OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:19736020</ref><references group="xtra"/> | |||
[[Category: Glucokinase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Kamata, K.]] | |||
[[Category: Takahashi, K.]] | |||
[[Category: Allosteric activator]] | |||
[[Category: Alternative splicing]] | |||
[[Category: Atp-binding]] | |||
[[Category: Diabetes]] | |||
[[Category: Diabetes mellitus]] | |||
[[Category: Disease mutation]] | |||
[[Category: Glucokinase]] | |||
[[Category: Glycolysis]] | |||
[[Category: Kinase]] | |||
[[Category: Nucleotide-binding]] | |||
[[Category: Polymorphism]] | |||
[[Category: Transferase]] | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 14:04:44 2009'' | |||
Revision as of 12:04, 7 October 2009
Human glucokinase in complex with a synthetic activator
Template:ABSTRACT PUBMED 19736020
Disease
Known disease associated with this structure: Diabetes mellitus, gestational OMIM:[138079], Diabetes mellitus, noninsulin-dependent, late onset OMIM:[138079], Diabetes mellitus, permanent neonatal OMIM:[138079], Hyperinsulinemic hypoglycemia, familial, 3 OMIM:[138079], MODY, type II OMIM:[138079]
About this Structure
3H1V is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Takahashi K, Hashimoto N, Nakama C, Kamata K, Sasaki K, Yoshimoto R, Ohyama S, Hosaka H, Maruki H, Nagata Y, Eiki J, Nishimura T. The design and optimization of a series of 2-(pyridin-2-yl)-1H-benzimidazole compounds as allosteric glucokinase activators. Bioorg Med Chem. 2009 Oct 1;17(19):7042-51. Epub 2009 May 21. PMID:19736020 doi:10.1016/j.bmc.2009.05.037
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