C-Myc: Difference between revisions
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Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | ||
==Origins of C-myc== | |||
In 1911 a virologist named Peyton Rous saw that sarcoma in chickens could be transmitted through cell free extracts from the sarcoma tumors. This suggested that a virus was possibly the etiologic agent of the sarcoma. To see if it was true scientists studied an avian retrovirus which was found to induce myeloid leukemia, sarcomas, liver, kidney, and other tumors. They also found a gene in the body named V-myc. V-myc (myelocytomatosis viral oncogene homolog 1) is the gene in the body that aided the virus in causing cancer in the chickens. Soon after they found genes in humans with Burkitt's Lyphoma that had a similar makeup to the V-myc gene. Later they found that C-myc like V-myc causes cancer when the gene is changed or affected by something else. | |||
==C-myc Bonding== | ==C-myc Bonding== | ||
