Human APP Intracellular Domain Complex with Fe65-PTB2: Difference between revisions

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== Location ==
== Location ==
[SUBCELLULAR LOCATION] Cell membrane. Cytoplasm. Nucleus. Note=In
Fe65 could be located in cell membrane, cytoplasm, nucleus. In normal conditions, it mainly localizes to the cytoplasm, while a
            normal conditions, it mainly localizes to the cytoplasm, while a
small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released
            small fraction is tethered to the cell membrane via its interaction
from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP.
            with APP. Following exposure to DNA damaging agents, it is released
http://www.ncbi.nlm.nih.gov/protein/Q9QXJ1.2?ordinalpos=6&itool=EntrezSystem2.PEntrez.Sequence.Sequence_ResultsPanel.Sequence_RVDocSum
            from cell membrane and translocates to the nucleus. Nuclear
            translocation is under the regulation of APP.http://www.ncbi.nlm.nih.gov/protein/Q9QXJ1.2?ordinalpos=6&itool=EntrezSystem2.PEntrez.Sequence.Sequence_ResultsPanel.Sequence_RVDocSum
 


== APP and Alzheimer disease ==
== APP and Alzheimer disease ==
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