Human APP Intracellular Domain Complex with Fe65-PTB2: Difference between revisions
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== APP and Alzheimer disease == | == APP and Alzheimer disease == | ||
Aβ peptides are generated in neuronal secretory vesicles by proteolytic cleavage of the amyloid precursor protein (APP) by proteases, called β-secretase and γ-secretase that cleave at the N-terminus and variant C-termini of Aβ within APP, respectively, resulting in Aβ of 40 or 42 amino acids (Aβ40 and Aβ42, respectively)<ref> | Aβ peptides are generated in neuronal secretory vesicles by proteolytic cleavage of the amyloid precursor protein (APP) by proteases, called β-secretase and γ-secretase that cleave at the N-terminus and variant C-termini of Aβ within APP, respectively, resulting in Aβ of 40 or 42 amino acids (Aβ40 and Aβ42, respectively)<ref>Vivian Hook, Israel Schechter, Hans-Ulrich Demuth, Gregory Hook. Alternative Pathways for Production of Beta-Amyloid Peptides of Alzheimer's Disease.Biol Chem. 2008 August; 389(8): 993-1006. [http://www.ncbi.nlm.nih.gov:80/pmc/articles/PMC2654319/?tool=pmcentrez PMCID: PMC2654319]</ref> | ||
== References == | == References == | ||
