Kwon sandbox: Difference between revisions
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A mutated version of Myc is found in many cancers which causes Myc to be persistently expressed. This leads to the unregulated expression of many genes some of which are involved in cell proliferation and results in the formation of [[cancer]]. A common [[translocation]] which involves Myc is t(8:14) is involved in the development of a lymphoma. A recent study demontrated that temporary inhibition of Myc selectively kills mouse lung cancer cells, making it a potential cancer drug target.<ref>{{cite journal | A mutated version of Myc is found in many cancers which causes Myc to be persistently expressed. This leads to the unregulated expression of many genes some of which are involved in cell proliferation and results in the formation of [[cancer]]. A common [[translocation]] which involves Myc is t(8:14) is involved in the development of a lymphoma. A recent study demontrated that temporary inhibition of Myc selectively kills mouse lung cancer cells, making it a potential cancer drug target.<ref>{{cite journal | ||
==Discovery== | ==Discovery== | ||
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Myc is activated upon various [[mitogen|mitogenic signal]]s such as [[Wnt signalling pathway|Wnt]], [[Sonic hedgehog|Shh]] and [[Epidermal growth factor|EGF]] (via the [[MAPK/ERK pathway]]). | Myc is activated upon various [[mitogen|mitogenic signal]]s such as [[Wnt signalling pathway|Wnt]], [[Sonic hedgehog|Shh]] and [[Epidermal growth factor|EGF]] (via the [[MAPK/ERK pathway]]). | ||
By modifying the expression of its target genes, Myc activation results in numerous biological effects. The first to be discovered was its capability to drive [[cell proliferation]] (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating [[cell growth]] (upregulates ribosomal RNA and proteins), [[apoptosis]] (downregulates [[Bcl-2]]), differentiation and [[stem cell]] self-renewal. Myc is a very strong [[Oncogene#Proto-oncogene|proto-oncogene]] and it is very often found to be [[upregulation|upregulated]] in many types of cancers. | By modifying the expression of its target genes, Myc activation results in numerous biological effects. The first to be discovered was its capability to drive [[cell proliferation]] (upregulates cyclins, downregulates p21), but it also plays a very important role in regulating [[cell growth]] (upregulates ribosomal RNA and proteins), [[apoptosis]] (downregulates [[Bcl-2]]), differentiation and [[stem cell]] self-renewal. Myc is a very strong [[Oncogene#Proto-oncogene|proto-oncogene]] and it is very often found to be [[upregulation|upregulated]] in many types of cancers. | ||
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