Kwon sandbox: Difference between revisions

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==Relevance to Cancer==
{{GNF_Protein_box
 
| image = C-Myc-DNA complex.png
In 1911 a virologist named Peyton Rous saw that sarcoma in chickens could be transmitted through cell free extracts from the sarcoma tumors. This suggested that a virus was possibly the etiologic agent of the sarcoma.  To see if it was true scientists studied an avian retrovirus which was found to induce myeloid leukemia, sarcomas, liver, kidney, and other tumors.  They also found a gene in the body named V-myc.  V-myc (myelocytomatosis viral oncogene homolog 1) is the gene in the body that aided the virus in causing cancer in the chickens.  Soon after they found genes in humans with Burkitt's Lyphoma that had a similar makeup to the V-myc gene.  Later they found that C-myc like V-myc causes cancer when the gene is changed or affected by something else.  
  | image_source = Structure of the c-Myc (red) in complex with Max (blue) and DNA ([[Protein_Data_Bank|PDB]] 1nkp). Both proteins are binding the major groove of the DNA by forming a fork-like structure.  


| PDB = {{PDB2|1nkp}}
| Name = V-myc myelocytomatosis viral oncogene homolog (avian)
| HGNCid = 7553
| Symbol = MYC
| AltSymbols =; c-Myc
| OMIM = 190080
| ECnumber = 
| Homologene = 31092
| MGIid = 97250
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005819 |text = spindle}}
| Process = {{GNF_GO|id=GO:0001836 |text = release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0008633 |text = activation of pro-apoptotic gene products}} {{GNF_GO|id=GO:0008634 |text = negative regulation of survival gene product activity}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Hs_EntrezGene = 4609
| Hs_Ensembl = ENSG00000136997
| Hs_RefseqProtein = NP_002458
| Hs_RefseqmRNA = NM_002467
| Hs_GenLoc_db =  hg18
| Hs_GenLoc_chr = 
| Hs_GenLoc_start = 
| Hs_GenLoc_end = 
| Hs_Uniprot = 
| Mm_EntrezGene = 17869
| Mm_Ensembl = ENSMUSG00000022346
| Mm_RefseqmRNA = NM_010849
| Mm_RefseqProtein = NP_034979
| Mm_GenLoc_db =  mm8
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 61815052
| Mm_GenLoc_end = 61820027
| Mm_Uniprot = O88594
}}


==Research in Structure and Function==
==Research in Structure and Function==
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