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| <scene name='C-Myc/Custom/2'>TextToBeDisplayed</scene> | | <scene name='C-Myc/Custom/2'>TextToBeDisplayed</scene> |
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| The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription].
| | cMyc is a protein that binds to DNA to regulate transcription. Bishop and collegues found viruses that induced chicken sarcomas and studied the virus’s genome to find the genotypic causation. The viral oncogene that caused the sarcomas was identified as v-myc. Later on the homologous gene in chickens was discovered, and called c-myc. These findings provided evidence that activated cMyc proteins were significant in cellular growth regulation. |
| Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer.
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| {{GNF_Protein_box
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| | image = C-Myc-DNA complex.png | |
| | image_source = Structure of the c-Myc (red) in complex with Max (blue) and DNA ([[Protein_Data_Bank|PDB]] 1nkp). Both proteins are binding the major groove of the DNA by forming a fork-like structure. | |
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| | PDB = {{PDB2|1nkp}} | |
| | Name = V-myc myelocytomatosis viral oncogene homolog (avian)
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| | HGNCid = 7553
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| | Symbol = MYC
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| | AltSymbols =; c-Myc
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| | OMIM = 190080
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| | ECnumber =
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| | Homologene = 31092
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| | MGIid = 97250
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| | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
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| | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005819 |text = spindle}}
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| | Process = {{GNF_GO|id=GO:0001836 |text = release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0006309 |text = DNA fragmentation during apoptosis}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006879 |text = cellular iron ion homeostasis}} {{GNF_GO|id=GO:0006919 |text = caspase activation}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0008629 |text = induction of apoptosis by intracellular signals}} {{GNF_GO|id=GO:0008633 |text = activation of pro-apoptotic gene products}} {{GNF_GO|id=GO:0008634 |text = negative regulation of survival gene product activity}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
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| | Hs_EntrezGene = 4609
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| | Hs_Ensembl = ENSG00000136997
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| | Hs_RefseqProtein = NP_002458
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| | Hs_RefseqmRNA = NM_002467
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| | Hs_GenLoc_db = hg18
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| | Hs_GenLoc_chr =
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| | Hs_GenLoc_start =
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| | Hs_GenLoc_end =
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| | Hs_Uniprot =
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| | Mm_EntrezGene = 17869
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| | Mm_Ensembl = ENSMUSG00000022346
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| | Mm_RefseqmRNA = NM_010849
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| | Mm_RefseqProtein = NP_034979
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| | Mm_GenLoc_db = mm8
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| | Mm_GenLoc_chr = 15
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| | Mm_GenLoc_start = 61815052
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| | Mm_GenLoc_end = 61820027
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| | Mm_Uniprot = O88594
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| }}
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| ==Research in Structure and Function== | | ==Research in Structure and Function== |
