Sandbox 1b41: Difference between revisions
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==The Active site gorge of AChE== | ==The Active site gorge of AChE== | ||
The active site of AChE | The active site of AChE involves two sites: the peripheral site and the catalytic site. | ||
[[Image: Sites de l'AChE.jpg|400 px|]] | [[Image: Sites de l'AChE.jpg|400 px|]] | ||
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In the "anionic" site, the <scene name='Sandbox_1b41/Anionic_site/1'>W86</scene> binds trimethylammonium group of ACh. | In the "anionic" site, the <scene name='Sandbox_1b41/Anionic_site/1'>W86</scene> binds trimethylammonium group of ACh. | ||
Further to these steps the substrat is well positioned to be hydrolysed. | Further to these steps the substrat is well positioned to be hydrolysed into acetic acid and cholin. | ||
[[Image: Hydrolyse ACh par AChE.jpg|500 px|]] | [[Image: Hydrolyse ACh par AChE.jpg|500 px|]] | ||
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===Inhibitors used as treatments=== | ===Inhibitors used as treatments=== | ||
We can find a lot of inhibitors such as | We can find a lot of inhibitors such as Alzheimer's disease drugs treatment. Actually, Alzheimer disease is a neurodegenerative disease in which ACh is less present. An inhibition approach can be used to increase the remaining of ACh in the synaptic cleft by inhibiting the action of AChE. These treatment include rivastigmine, donepezil and tacrine. However, those drugs don't cure this disease, but only delay its development. | ||
