Sandbox136: Difference between revisions
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Elie Peillon (talk | contribs) New page: {{STRUCTURE_1mg6 | PDB=1mg6 | SCENE= }} '''==Introduction==''' Lys49 Phospholipase A2 (K49 PLA2), is a protein extracted from Antropoides nummifer (a snake from central ameri... |
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the NH main chain of R34 and the O2 atom of SO42- | the NH main chain of R34 and the O2 atom of SO42- | ||
O4 atom is anchored between K53 Nζ and R34 Nη2 | O4 atom is anchored between K53 Nζ and R34 Nη2 | ||
[[Image:Anion_Interactions.jpg ]] | |||
This anion-binding site is supposed to play a role in the fixation of inhibitors but his function remains unknown. In the crystallization state (pH5), the protein is in a monomer state whereas in a solution at physiological pH, a dimerization occurs . The dimerization happened thanks to interactions at the interface of the N-terminal and β-wing regions . Studies have shown that Lys49 PLA2 is active only in the dimer state | This anion-binding site is supposed to play a role in the fixation of inhibitors but his function remains unknown. In the crystallization state (pH5), the protein is in a monomer state whereas in a solution at physiological pH, a dimerization occurs . The dimerization happened thanks to interactions at the interface of the N-terminal and β-wing regions . Studies have shown that Lys49 PLA2 is active only in the dimer state | ||
