3hpt: Difference between revisions

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'''Unreleased structure'''
{{Seed}}
[[Image:3hpt.jpg|left|200px]]


The entry 3hpt is ON HOLD until sometime in the future
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Authors: Klei, H.E., Ghosh, K., Rushith, A., Kish, K.
===Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine===


Description: CRYSTAL STRUCTURE OF HUMAN FXA IN COMPLEX WITH (S)-2-CYANO-1-(2-METHYLBENZOFURAN-5-YL)-3-(2-OXO-1-(2-OXO-2-(PYRROLIDIN-1-YL)ETHYL)AZEPAN-3-YL)GUANIDINE


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  1 08:56:21 2009''
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{{ABSTRACT_PUBMED_19541481}}
 
==About this Structure==
3HPT is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPT OCA].
 
==Reference==
<ref group="xtra">PMID:19541481</ref><references group="xtra"/>
[[Category: Coagulation factor Xa]]
[[Category: Homo sapiens]]
[[Category: Ghosh, K.]]
[[Category: Kish, K.]]
[[Category: Klei, H E.]]
[[Category: Rushith, A.]]
[[Category: Blood clotting]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation factor]]
[[Category: Calcium]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Disulfide bond]]
[[Category: Egf-like domain]]
[[Category: Epidermal growth factor like domain]]
[[Category: Gamma-carboxyglutamic acid]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Hydroxylation]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Serine protease]]
[[Category: Zymogen]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 19:36:45 2009''

Revision as of 17:36, 18 November 2009

File:3hpt.jpg

Template:STRUCTURE 3hpt

Crystal structure of human FxA in complex with (S)-2-cyano-1-(2-methylbenzofuran-5-yl)-3-(2-oxo-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-3-yl)guanidine

Template:ABSTRACT PUBMED 19541481

About this Structure

3HPT is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Shi Y, Zhang J, Shi M, O'Connor SP, Bisaha SN, Li C, Sitkoff D, Pudzianowski AT, Chong S, Klei HE, Kish K, Yanchunas J Jr, Liu EC, Hartl KS, Seiler SM, Steinbacher TE, Schumacher WA, Atwal KS, Stein PD. Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4034-41. Epub 2009 Jun 13. PMID:19541481 doi:10.1016/j.bmcl.2009.06.014

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