Reverse transcriptase: Difference between revisions
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<applet load='3jyt' size='400' color='white' frame='true' align='right' caption='Reverse Transcriptase' scene='Reverse_transcriptase/Initial/1' /> | <applet load='3jyt' size='400' color='white' frame='true' align='right' caption='Reverse Transcriptase' scene='Reverse_transcriptase/Initial/1' /> | ||
Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, in company of [[Hiv protease]] and [[Hiv integrase]], the most important part of the protein system | Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, in company of [[Hiv protease]] and [[Hiv integrase]], the most important part of the protein system involved in the process of infection of viruses like HIV-1, MuLV and AMV, and has the unusual property of transcribing ssRNA into dsDNA going against the Central Dogma of Molecular Biology. | ||
Reverse Transcriptase is a RNA-dependent DNA Polymerase, | Since its discovery in 1970, the study of its properties and mechanisms of action have been of high interest among the scientific community due to the unique properties that makes it an important medical target enzyme. | ||
==Structure and Function== | |||
This Reverse Transcriptase is a RNA-dependent <scene name='Reverse_transcriptase/Chains/1'>2-chain</scene> DNA Polymerase has an usual length of 1000 residues (560 in chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets <scene name='Reverse_transcriptase/Secondary/1'>secondary structures</scene>. Chain A has an usual | |||
==See Also== | ==See Also== | ||