Reverse transcriptase: Difference between revisions
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<applet load='3jyt' size='350' color='white' frame='true' align='right' caption='Reverse Transcriptase' scene='Reverse_transcriptase/Initial/1' /> | <applet load='3jyt' size='350' color='white' frame='true' align='right' caption='Reverse Transcriptase' scene='Reverse_transcriptase/Initial/1' /> | ||
Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, in company of [[Hiv protease|Protease]] and [[Hiv integrase|Integrase]], the most important part of the protein system involved in the process of infection of viruses like HIV | Being the protein that gives their name to Retroviruses, Reverse Transcriptase is, in company of [[Hiv protease|Protease]] and [[Hiv integrase|Integrase]], the most important part of the protein system involved in the process of infection of viruses like HIV, MuLV and AMV, and has the unusual property of transcribing ssRNA into dsDNA going against the Central Dogma of Molecular Biology. | ||
Since its discovery in 1970, the study of its properties and mechanisms of action have been of high interest among the scientific community due to the unique properties that makes it an important medical target enzyme and important tool for genetic engineering applications like RT-PCR in the construction of cDNA libraries. | Since its discovery in 1970, the study of its properties and mechanisms of action have been of high interest among the scientific community due to the unique properties that makes it an important medical target enzyme and important tool for genetic engineering applications like RT-PCR in the construction of cDNA libraries. | ||
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* [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb33_1.html Molecule of the Month (09/2002) at RCSB PDB] | * [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb33_1.html Molecule of the Month (09/2002) at RCSB PDB] | ||
* List of Reverse Transcriptase articles at [http://www.proteopedia.org/wiki/index.php/Category:Reverse_transcriptase Proteopedia] and at [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb33_report.html RCSB PDB] | * List of Reverse Transcriptase articles at [http://www.proteopedia.org/wiki/index.php/Category:Reverse_transcriptase Proteopedia] and at [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb33_report.html RCSB PDB] | ||
==References== | |||
*Consurf Server Data Base. [http://consurfdb.tau.ac.il/chain_selection.php?pdb_ID=1JLB] Evolutionary conservation profile for Reverse Transcriptase PDB file 1JLB <!--accessed November 28, 2009--> | |||
*University College London. [http://www.biochem.ucl.ac.uk/bsm/xtal/teach/repl/rt.html] DNA Replication Enzymes <!--accessed November 28, 2009--> | |||
