Human beta two microglobulin: Difference between revisions

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==This is a placeholder==
==Human beta two microglubulin==
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Huamn β2-Microglobulin (b2m) is the non-covalently bound light chain of the human class I major histocompatibility complex
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(MHC-I). its function is to ensure proper folding and cell-surface expression of MHC-1.  
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The natural turnover of MHC-I gives rise to the release of b2m into plasmatic fluids at ~0.1 um and to its catabolism in the kidney
In case of renal dysfunction, b2m concentration increases up to 60-fold, giving rise to pathogenic accumulation of filamentous structures, displaying the typical properties of amyloid fibrils, principally in the joints and connective tissue.


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{{STRUCTURE_1duz |  PDB=1duz  |  SCENE= }}
 
{{STRUCTURE_1duz |  PDB=1duz  |  SCENE= }}
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