Highest impact structures: Difference between revisions
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This list is in chronological order. | This list is in chronological order. | ||
* '''1953 - DNA double helix''' (B form): Although Watson and Crick's model was theoretical, it was essentially correct, and for the first time explained the ability of genes to be faithfully copied during cell division. It was not confirmed by atomic resolution X-ray crystallography until 1973, using RNA dinucleotide crystals. A full turn of B form DNA was not solved until 1980 (cf. [[1bna]]), 27 years after Watson and Crick's model. More: click on DNA at the [http://atlas.molviz.org Atlas of Macromolecules] | * '''1953 - [[DNA]] double helix''' (B form): Although Watson and Crick's model was theoretical, it was essentially correct, and for the first time explained the ability of genes to be faithfully copied during cell division. It was not confirmed by atomic resolution X-ray crystallography until 1973, using RNA dinucleotide crystals. A full turn of B form DNA was not solved until 1980 (cf. [[1bna]]), 27 years after Watson and Crick's model. More: click on DNA at the [http://atlas.molviz.org Atlas of Macromolecules] | ||
* '''1958 - [[Myoglobin]]''': As the first protein structure that was determined, it is hard to exaggerate its impact. Before this structure, proteins were widely believed to be colloidal, and protein crystals were expected to contain highly symmetrical structures. The irregular fold of myoglobin (see photo of an early low-resolution model at [[Nobel Prizes for 3D Molecular Structure]]) was a huge surprise. | * '''1958 - [[Myoglobin]]''': As the first protein structure that was determined, it is hard to exaggerate its impact. Before this structure, proteins were widely believed to be colloidal, and protein crystals were expected to contain highly symmetrical structures. The irregular fold of myoglobin (see photo of an early low-resolution model at [[Nobel Prizes for 3D Molecular Structure]]) was a huge surprise. | ||
