3kck: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
3KCK is a 1 chain structure | 3KCK is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KCK OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 09:58:31 2010'' | ||
Revision as of 07:58, 17 February 2010
A Novel Chemotype of Kinase Inhibitors
Template:ABSTRACT PUBMED 19945871
Disease
Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[147796], Myelofibrosis, idiopathic OMIM:[147796], Myeloproliferative disorder with erythrocytosis OMIM:[147796], Polycythemia vera OMIM:[147796], Thrombocythemia, essential OMIM:[147796], Budd-Chiari syndrome OMIM:[147796]
About this Structure
3KCK is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Wang T, Ledeboer MW, Duffy JP, Salituro FG, Pierce AC, Zuccola HJ, Block E, Shlyakter D, Hogan JK, Bennani YL. A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):153-6. Epub 2009 Nov 12. PMID:19945871 doi:10.1016/j.bmcl.2009.11.021
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Pages with broken file links
- Homo sapiens
- Non-specific protein-tyrosine kinase
- Ledeboer, M W.
- Wang, T.
- Zuccola, H J.
- Atp-binding
- Chromosomal rearrangement
- Disease mutation
- Inhibitor
- Jak2
- Janus kinase
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Polymorphism
- Proto-oncogene
- Sh2 domain
- Transferase
- Tyrosine-protein kinase
