Jasper Small Lactate Sandbox 1: Difference between revisions
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[[Image:1i10.png|left|200px]] | [[Image:1i10.png|left|200px]] | ||
{{STRUCTURE_1i10| PDB=1i10 | SCENE= }} | {{STRUCTURE_1i10| PDB=1i10 | SCENE= }} | ||
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LDH preforms an important metabolic function in the body. The enzyme catalyzes both the conversion of pyruvate to lactose as well as the conversion of lactose to pyruvate. The conversion of pyruvate to lactose occurs in the muscles of the body when oxygen is absent. The lactate acid is then moved back to the liver where LDH catalyzes the Cori cycle which converts the lactose back into pyruvate. The reaction is also important as it is coupled with the interconversion of NADH and NAD+. | LDH preforms an important metabolic function in the body. The enzyme catalyzes both the conversion of pyruvate to lactose as well as the conversion of lactose to pyruvate. The conversion of pyruvate to lactose occurs in the muscles of the body when oxygen is absent. The lactate acid is then moved back to the liver where LDH catalyzes the Cori cycle which converts the lactose back into pyruvate. The reaction is also important as it is coupled with the interconversion of NADH and NAD+. | ||
==Forms== | |||
LDH is a quaternary protein formed of the combination of two subunits, M and H (Muscle and Heart) into a structure of four of the subunits. The various combinations found in the human body are: | |||
* LDH-1 (4H) - in the heart | |||
* LDH-2 (3H1M) - in the reticuloendothelial system | |||
* LDH-3 (2H2M) - in the lungs | |||
* LDH-4 (1H3M) - in the kidneys | |||
* LDH-5 (4M) - in the liver and striated muscle | |||
==Catalysis== | ==Catalysis== | ||
