Group:SMART:2010 Pingry SMART Team Models: Difference between revisions

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== AdhD K249G/H255R double mutant and Self-assembly into hydrogels ==
== AdhD K249G/H255R double mutant and Self-assembly into hydrogels ==
<applet load='AdhD_with_three_cofactors_no_H.pdb' size='400' frame='true' align='left' caption='AdhD K249G/H255R double mutant' scene='2010_Pingry_SMART_Team/Adhd_0/2'/>
<applet load='AdhD_with_three_cofactors_no_H.pdb' size='400' frame='true' align='left' caption='AdhD K249G/H255R double mutant' scene='2010_Pingry_SMART_Team/Adhd_0/2'/>
<scene name='2010_Pingry_SMART_Team/Adhd_0/3'>Show NAD</scene>
<scene name='2010_Pingry_SMART_Team/Adhd_0/4'>Show NADP</scene>
<scene name='2010_Pingry_SMART_Team/Adhd_0/5'>Show nicotimanide</scene>
<scene name='2010_Pingry_SMART_Team/Adhd_0/2'>Remove cofactor</scene>
 
 
==PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)==
==PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)==


<applet load='1a80' size='400' frame='true' align='left' caption='1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)' scene='2010_Pingry_SMART_Team/1a80-original/22'/>  
<applet load='1a80' size='400' frame='true' align='left' caption='1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)' scene='2010_Pingry_SMART_Team/1a80-original/22'/>  
'''Design description'''
2,5-DKGR A possesses a parallel alpha-beta structural motif of the <scene name='2010_Pingry_SMART_Team/1a80-default/2'>eight alpha helices (highlighted red) and eight beta strands (highlighted blue)</scene> found in all enzymes in the aldo-keto reductase(AKR) family.


{{Clear}}
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==PDB ID: 1m9h, Mutant 2,5-diketo-d-gluconic acid reductase with NADH (mutant)==


<applet load='1m9h' size='400' frame='true' align='left' caption='1m9h, Mutant 2,5-diketo-d-gluconic acid reductase with NADH' scene='2010_Pingry_SMART_Team/1m9h_default/1'/>
<applet load='1m9h' size='400' frame='true' align='left' caption='1m9h, Mutant 2,5-diketo-d-gluconic acid reductase with NADH' scene='2010_Pingry_SMART_Team/1m9h_default/1'/>
==PDB ID: 1m9h, Mutant 2,5-diketo-d-gluconic acid reductase with NADH (mutant)==


{{Clear}}
{{Clear}}


=='''Inherent dual cofactor use, Xylose reductase'''==
==PDB ID: 1k8c, Xylose reductase with NADP+==
 
 
<applet load='1K8C_chainD.pdb' size='400' frame='true' align='left' caption='1k8c, Xylose reductase with NADP+' scene='2010_Pingry_SMART_Team/1k8c_nospindefault/1'/>
<applet load='1K8C_chainD.pdb' size='400' frame='true' align='left' caption='1k8c, Xylose reductase with NADP+' scene='2010_Pingry_SMART_Team/1k8c_nospindefault/1'/>
===PDB ID: 1k8c, Xylose reductase with NADP+===
 
{{Clear}}
 
==PDB ID: 1mi3, Xylose reductase with NAD+==
<applet load='1MI3_chainA.pdb' size='400' frame='true' align='left' caption='1mi3, Xylose reductase with NAD+' scene='2010_Pingry_SMART_Team/1mi3_nospindefault/1'/>
<applet load='1MI3_chainA.pdb' size='400' frame='true' align='left' caption='1mi3, Xylose reductase with NAD+' scene='2010_Pingry_SMART_Team/1mi3_nospindefault/1'/>


===PDB ID: 1mi3, Xylose reductase with NAD+===
{{Clear}}


 
==PDB ID: 1lwi, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with NADP+ cofactor==
==='''A structure of an AKR with its substrate, 3-alpha-hydroxysteroid dihydrodiol dehydrogenase'''===
<applet load='1LWI_chainA.pdb' size='400' frame='true' align='left' caption='1lwi, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with NADP+ cofactor' scene='2010_Pingry_SMART_Team/1lwi_default/7'/>
<applet load='1LWI_chainA.pdb' size='400' frame='true' align='left' caption='1lwi, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with NADP+ cofactor' scene='2010_Pingry_SMART_Team/1lwi_default/7'/>
====PDB ID: 1lwi, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with NADP+ cofactor====


{{Clear}}
====PDB ID: 1afs, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with cofactor and testosterone====
<applet load='1AFS_chainA.pdb' size='400' frame='true' align='left' caption='1afs, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with cofactor and testosterone' scene='2010_Pingry_SMART_Team/1afs_default/7'/>
<applet load='1AFS_chainA.pdb' size='400' frame='true' align='left' caption='1afs, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with cofactor and testosterone' scene='2010_Pingry_SMART_Team/1afs_default/7'/>


====PDB ID: 1afs, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with cofactor and testosterone====
{{Clear}}

Revision as of 02:28, 8 March 2010

Return to 2010 SMART Team Page: 2010 Pingry SMART Team

AdhD K249G/H255R double mutant and Self-assembly into hydrogels

AdhD K249G/H255R double mutant

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PDB ID: 1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)

1a80, 2,5-diketo-d-gluconic acid reductase with NADPH (wild-type)

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PDB ID: 1m9h, Mutant 2,5-diketo-d-gluconic acid reductase with NADH (mutant)

1m9h, Mutant 2,5-diketo-d-gluconic acid reductase with NADH

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PDB ID: 1k8c, Xylose reductase with NADP+

1k8c, Xylose reductase with NADP+

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PDB ID: 1mi3, Xylose reductase with NAD+

1mi3, Xylose reductase with NAD+

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PDB ID: 1lwi, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with NADP+ cofactor

1lwi, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with NADP+ cofactor

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PDB ID: 1afs, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with cofactor and testosterone

1afs, Rat liver 3-alpha-hydroxysteroid dihydrodiol dehydrogenase with cofactor and testosterone

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