Urate Oxidase: Difference between revisions
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Urate oxidase has the function of preventing uric acid levels from becoming too high in certain organisms, including bacteria, plants and some mammals. It is found in highest concentrations in the liver, but it is found in the peroxisomes of all cells. Although this enzyme has been found in many organisms, it is absent in higher apes and humans (this is a result of a mutation in the codon for Arg 176 to a stop codon). | Urate oxidase has the function of preventing uric acid levels from becoming too high in certain organisms, including bacteria, plants and some mammals. It is found in highest concentrations in the liver, but it is found in the peroxisomes of all cells. Although this enzyme has been found in many organisms, it is absent in higher apes and humans (this is a result of a mutation in the codon for Arg 176 to a stop codon). | ||
Although the exact mechanism by which urate oxidase carries out its function is yet unknown, | Although the exact mechanism by which urate oxidase carries out its function is yet unknown, most studies agree that the catalytic proton transfer previously described is involved. After compiling data from multiple studies, Collac'h ''et at.'' came up with a plasuible mechanism. This mechanism involves | ||
== Medical Implications == | == Medical Implications == | ||
