Jake Ezell Sandbox 2: Difference between revisions
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The evolutionary past of MDH shows a divergence to form lactate dehydrogenase (LDH) which functions in a very similar way to MDH. Although there is a very low sequence conservation among MDH and LDH’s [http://blast.ncbi.nlm.nih.gov/Blast.cgi] the structure of the enzyme has remained relatively conserved. The key difference between the two is in the substate: LDH catalyzes pyruvate to lactate. | The evolutionary past of MDH shows a divergence to form lactate dehydrogenase (LDH) which functions in a very similar way to MDH. Although there is a very low sequence conservation among MDH and LDH’s [http://blast.ncbi.nlm.nih.gov/Blast.cgi] the structure of the enzyme has remained relatively conserved. The key difference between the two is in the substate: LDH catalyzes pyruvate to lactate. | ||
==References== | |||
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