Sandbox 179: Difference between revisions

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Protein Function

Pepsin is one of three proteolytic, or protein degrading enzymes in the digestive system. It resides in the alimentary canal and is produced by mucosal cells. Pepsin degrades peptides, and is optimally active at low pHs <ref> ~~X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution. 1990;214~~:~~199-222~~</ref>. Pepsin is an aspartic proteinase, more specifically a eukaryotic aspartic protease enzyme. Pepsin was among the first enzymes to be isolated in crystalline form <ref name="flexible">PMID: 2217165</ref>. Aspartic proteinases are widespread in nature, and pepsin in particular has been known to be medically important <ref> The prosegment catalyzed pepsin folding to a kinetically trapped native state. Biochemistry 49:365-371</ref>.

Pepsin is one of three proteolytic, or protein degrading enzymes in the digestive system. It resides in the alimentary canal and is produced by mucosal cells. Pepsin degrades peptides, and is optimally active at low pHs <ref name="Xray">PMID: 2115088</ref>. Pepsin is an aspartic proteinase, more specifically a eukaryotic aspartic protease enzyme. Pepsin was among the first enzymes to be isolated in crystalline form <ref name="flexible">PMID: 2217165</ref>. Aspartic proteinases are widespread in nature, and pepsin in particular has been known to be medically important <ref> The prosegment catalyzed pepsin folding to a kinetically trapped native state. Biochemistry 49:365-371</ref>.

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Overall Structure

Sandbox 179: Difference between revisions

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 Protein Function
-Pepsin is one of three proteolytic, or protein degrading enzymes in the digestive system. It resides in the alimentary canal and is produced by mucosal cells. Pepsin degrades peptides, and is optimally active at low pHs <ref> X-ray analyses of aspartic proteinases. II. Three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 A resolution. 1990;214:199-222</ref>. Pepsin is an aspartic proteinase, more specifically a eukaryotic aspartic protease enzyme. Pepsin was among the first enzymes to be isolated in crystalline form <ref name="flexible">PMID: 2217165</ref>.  Aspartic proteinases are widespread in nature, and pepsin in particular has been known to be medically important <ref> The prosegment catalyzed pepsin folding to a kinetically trapped native state. Biochemistry 49:365-371</ref>.
+Pepsin is one of three proteolytic, or protein degrading enzymes in the digestive system. It resides in the alimentary canal and is produced by mucosal cells. Pepsin degrades peptides, and is optimally active at low pHs <ref name="Xray">PMID: 2115088</ref>. Pepsin is an aspartic proteinase, more specifically a eukaryotic aspartic protease enzyme. Pepsin was among the first enzymes to be isolated in crystalline form <ref name="flexible">PMID: 2217165</ref>.  Aspartic proteinases are widespread in nature, and pepsin in particular has been known to be medically important <ref> The prosegment catalyzed pepsin folding to a kinetically trapped native state. Biochemistry 49:365-371</ref>.
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 Overall Structure