Sandbox 179: Difference between revisions
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=='''Pepsin'''== | =='''Pepsin'''== | ||
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{{STRUCTURE_5pep| | {{STRUCTURE_5pep | PDB=5pep | SCENE=Sandbox_179/Default/1}} | ||
---- | ---- | ||
==Protein Function== | ==Protein Function== | ||
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Once denatured, pepsin is unable to refold to an active native state upon returning from denaturing conditions. One proposed solution for this is that pepsin formation depends on a separate prosegment (PS) domain. When returning from the denatured state, the denatured pepsin first has to bypass a large folding barrier and then in the presence of PS the native state can become thermodynamically stable. The PS therefore can catalyze pepsin folding by stabilizing the transition state <ref name="native" /> . | Once denatured, pepsin is unable to refold to an active native state upon returning from denaturing conditions. One proposed solution for this is that pepsin formation depends on a separate prosegment (PS) domain. When returning from the denatured state, the denatured pepsin first has to bypass a large folding barrier and then in the presence of PS the native state can become thermodynamically stable. The PS therefore can catalyze pepsin folding by stabilizing the transition state <ref name="native" /> . | ||
<scene name='Sandbox_179/Default/1'>TextToBeDisplayed</scene> | |||
<scene name='Sandbox_179/Asp/1'>Asp</scene> | |||
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=References= | =References= | ||
<references/> | <references/> | ||
