Sandbox 174: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Simon Loewen (talk | contribs) No edit summary |
Simon Loewen (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
=Alpha-Bungarotoxin= | =Alpha-Bungarotoxin= | ||
Alpha-Bungarotoxin (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake commonly known as kraits. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain. | Alpha-Bungarotoxin (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake belonging to a group commonly known as kraits. Belonging to the Elapidae Family, which consist of cobras, kraits, tiger snakes, and mambas, the venom of ''Bungarus multicuntus'' is a complex mixture of many different molecules<ref>Love, A.R (FINISH)</ref> α-BGT belongs to a family of homologous proteins that act as a neurotoxic agent in the venom of these snakes. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain. | ||
=Structure= | =General Structure= | ||
[[Image:alpha-bungarotoxin1.PNG]] | [[Image:alpha-bungarotoxin1.PNG]] | ||
== | The family of neurotoxins | ||
==Active sites & == | |||
=Functions= | =Functions= | ||
Elapidae neurotoxins bind specifically and tightly in a non-covalent manner to the nicotinic acetylcholine receptors in cholinergic synapses of their victims. This prevents normal neurotransmitter-induced channel opening, which in turn blocks postsynaptic membrane depolarization<ref>Love. A.R (FINISH)</ref>. | |||
==α7 nicotinic acetylcholine receptor binding== | ==α7 nicotinic acetylcholine receptor binding== | ||
Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref name="main">a-Bungarotoxin Binding to Hippocampal Interneurons: | Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref name="main">a-Bungarotoxin Binding to Hippocampal Interneurons: | ||
lmmunocytochemical Characterization and Effects on Growth Factor | lmmunocytochemical Characterization and Effects on Growth Factor | ||
Expression</ref>. | Expression</ref>. Second note to refd<ref>article 2 </ref> | ||
