Prolyl Endopeptidase: Difference between revisions

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=== Celiac Disease ===

[http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease](CD) is a genetic disorder marked by diarrhea, fatigue, weight loss, and villous atrophy due to the consumption of gluten and other [http://en.wikipedia.org/wiki/Prolamin prolamins] found in wheat and wheat subspecies. The symptoms of CD are due to an auto-immune inflammatory reaction that occurs in the small intestine due to [http://en.wikipedia.org/wiki/Prolamin prolamins]. [http://en.wikipedia.org/wiki/Prolamin ~~Prolamins~~] are rich in ~~proline residues~~ and ~~known~~ to be ~~resistant~~ to ~~many proteases~~

[http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease](CD) is a genetic disorder marked by diarrhea, fatigue, weight loss, and villous atrophy due to the consumption of certain proteins such as gluten and other [http://en.wikipedia.org/wiki/Prolamin prolamins] found in wheat and wheat subspecies. The symptoms of CD are due to an auto-immune inflammatory reaction that occurs in the small intestine due to [http://en.wikipedia.org/wiki/Prolamin prolamins] that are rich in proline residues and known to be resistant to many proteases.

There is currently no cure for [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease] and the main treatment is to simply avoid eating [http://en.wikipedia.org/wiki/Prolamin prolamin] containing foods.

Prolyl endopeptidases are a promising therapeutic agent due to their ability to degrade the protein rich [http://en.wikipedia.org/wiki/Prolamin prolamins] and inhibit the inflammatory reaction. An early idea for treatment is to orally administer certain microbial PEPs which could directly degrade [http://en.wikipedia.org/wiki/Prolamin prolamins] in the intestine and reduce the auto-immune response. The key for this possibility is to be able to protect the PEPs from being degraded by gastric acids while allowing them to be able to be functional in the small intestine.

Prolyl Endopeptidase: Difference between revisions

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@@ Line 27: / Line 27: @@
 === Celiac Disease ===
-[http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease](CD) is a genetic disorder marked by diarrhea, fatigue, weight loss, and villous atrophy due to the consumption of gluten and other [http://en.wikipedia.org/wiki/Prolamin prolamins] found in wheat and wheat subspecies. The symptoms of CD are due to an auto-immune inflammatory reaction that occurs in the small intestine due to [http://en.wikipedia.org/wiki/Prolamin prolamins]. [http://en.wikipedia.org/wiki/Prolamin Prolamins] are rich in proline residues and known to be resistant to many proteases
+[http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease](CD) is a genetic disorder marked by diarrhea, fatigue, weight loss, and villous atrophy due to the consumption of certain proteins such as gluten and other [http://en.wikipedia.org/wiki/Prolamin prolamins] found in wheat and wheat subspecies. The symptoms of CD are due to an auto-immune inflammatory reaction that occurs in the small intestine due to [http://en.wikipedia.org/wiki/Prolamin prolamins] that are rich in proline residues and known to be resistant to many proteases.
+There is currently no cure for [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease] and the main treatment is to simply avoid eating [http://en.wikipedia.org/wiki/Prolamin prolamin] containing foods.
+Prolyl endopeptidases are a promising therapeutic agent due to their ability to degrade the protein rich [http://en.wikipedia.org/wiki/Prolamin prolamins] and inhibit the inflammatory reaction. An early idea for treatment is to orally administer certain microbial PEPs which could directly degrade [http://en.wikipedia.org/wiki/Prolamin prolamins] in the intestine and reduce the auto-immune response. The key for this possibility is to be able to protect the PEPs from being degraded by gastric acids while allowing them to be able to be functional in the small intestine.