Prolyl Endopeptidase: Difference between revisions
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There is currently no cure for [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease] and the main treatment is to simply avoid eating [http://en.wikipedia.org/wiki/Prolamin prolamin] containing foods. | There is currently no cure for [http://en.wikipedia.org/wiki/Coeliac_disease Celiac Disease] and the main treatment is to simply avoid eating [http://en.wikipedia.org/wiki/Prolamin prolamin] containing foods. | ||
Prolyl endopeptidases are a promising therapeutic agent due to their ability to degrade the protein rich [http://en.wikipedia.org/wiki/Prolamin prolamins] and inhibit the inflammatory reaction. An early idea for treatment is to orally administer certain microbial PEPs which could directly degrade [http://en.wikipedia.org/wiki/Prolamin prolamins] in the intestine and reduce the auto-immune response. The key for this possibility is to be able to protect the PEPs from being degraded by gastric acids while allowing them to be able to be functional in the small intestine. | Prolyl endopeptidases are a promising therapeutic agent due to their ability to degrade the protein rich [http://en.wikipedia.org/wiki/Prolamin prolamins] and inhibit the inflammatory reaction. An early idea for treatment is to orally administer certain microbial PEPs which could directly degrade [http://en.wikipedia.org/wiki/Prolamin prolamins] in the intestine and reduce the auto-immune response. The key for this possibility is to be able to protect the PEPs from being degraded by gastric acids while allowing them to be able to be functional in the small intestine once the acidity is decreased. | ||
=== Neurological Disorders === | === Neurological Disorders === | ||
