Sandbox 156: Difference between revisions

Line 36:

The active site, also the chloramphenicol binding site, catalyzes sequential acetylations of the chloramphenicol molecule. This is initiated by the deprotonation of the 3-hydroxyl of chloramphenicol by <scene name='Sandbox_156/Scene_two/1'>His-195</scene><ref>PMID:2015231</ref>. Numerous hydrogen bonds are present and, importantly, van der Waals interactions between the benzene ring of the <scene name='Sandbox_156/Scene_4/1'>Tyr-25</scene> residue and the imidazole ring. This van der Waals contact may help stabilize side-chain orientations, promoting specificity in the reaction. The acetyl group is already properly positioned after tunneling, and reacts readily without any major structural changes<ref>PMID: 3288984</ref>.

Ace-coa.gif

Sandbox 156: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

Revision as of 07:47, 26 March 2010 view source Anthony Daniele (talk \| contribs) 114 edits No edit summary ← Older edit		Revision as of 07:48, 26 March 2010 view source Anthony Daniele (talk \| contribs) 114 edits No edit summary Newer edit →
Line 36:		Line 36:
	The active site, also the chloramphenicol binding site, catalyzes sequential acetylations of the chloramphenicol molecule. This is initiated by the deprotonation of the 3-hydroxyl of chloramphenicol by <scene name='Sandbox_156/Scene_two/1'>His-195</scene><ref>PMID:2015231</ref>. Numerous hydrogen bonds are present and, importantly, van der Waals interactions between the benzene ring of the <scene name='Sandbox_156/Scene_4/1'>Tyr-25</scene> residue and the imidazole ring. This van der Waals contact may help stabilize side-chain orientations, promoting specificity in the reaction. The acetyl group is already properly positioned after tunneling, and reacts readily without any major structural changes<ref>PMID: 3288984</ref>.		The active site, also the chloramphenicol binding site, catalyzes sequential acetylations of the chloramphenicol molecule. This is initiated by the deprotonation of the 3-hydroxyl of chloramphenicol by <scene name='Sandbox_156/Scene_two/1'>His-195</scene><ref>PMID:2015231</ref>. Numerous hydrogen bonds are present and, importantly, van der Waals interactions between the benzene ring of the <scene name='Sandbox_156/Scene_4/1'>Tyr-25</scene> residue and the imidazole ring. This van der Waals contact may help stabilize side-chain orientations, promoting specificity in the reaction. The acetyl group is already properly positioned after tunneling, and reacts readily without any major structural changes<ref>PMID: 3288984</ref>.
	Ace-coa.gif		Ace-coa.gif