Ubiquitin Structure & Function: Difference between revisions
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At first, ubiquitin was believed to be a hormone involed in inducing the differentiation of lymphocytes and activating adenylate cyclase <ref>Vijay-Kumar, S., Begg, CE., Wilkinson, KD and Cook, WJ. 1985. Three-dimensional structure of ubiquitin of 2.8 angstrom resolution. ''Proc Natl Acad Sci'' 82:3582-3585</ref>. However, today ubiquitin is primarily known for its role in intracellular ATP-dependent protein degradation. This is accomplished by the formation of covalent conjugates between carboxyl terminals of ubiquitin and the target protein. | At first, ubiquitin was believed to be a hormone involed in inducing the differentiation of lymphocytes and activating adenylate cyclase <ref>Vijay-Kumar, S., Begg, CE., Wilkinson, KD and Cook, WJ. 1985. Three-dimensional structure of ubiquitin of 2.8 angstrom resolution. ''Proc Natl Acad Sci'' 82:3582-3585</ref>. However, today ubiquitin is primarily known for its role in intracellular ATP-dependent protein degradation. This is accomplished by the formation of covalent conjugates between carboxyl terminals of ubiquitin and the target protein. | ||
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