Sandbox 156: Difference between revisions

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Found in bacteria, the CAT III enzyme is responsible for conferring resistance of the antibiotic chloramphenicol to the cell. Chloramphenicol arrests protein synthesis by binding to the bacterial ribosomes and causing the inhibition of  
Found in bacteria, the CAT III enzyme is responsible for conferring resistance of the antibiotic chloramphenicol to the cell. Chloramphenicol arrests protein synthesis by binding to the bacterial ribosomes and causing the inhibition of  
[http://en.wikipedia.org/wiki/Peptidyl_transferase peptidyl transferase] activity<ref name=”Day”>PMID: 1544895</ref>. However, when CAT III catalyzes the acetylation of chloramphenicol, the antibiotic can no longer bind to the ribosomes and is rendered inactive. The genes for the enzyme are commonly found on the plasmid of the bacteria and have been found in a numerous bacterial species<ref>PMID: 2268277</ref>.
[http://en.wikipedia.org/wiki/Peptidyl_transferase peptidyl transferase] activity<ref name="Day">PMID: 1544895</ref>. However, when CAT III catalyzes the acetylation of chloramphenicol, the antibiotic can no longer bind to the ribosomes and is rendered inactive. The genes for the enzyme are commonly found on the plasmid of the bacteria and have been found in a numerous bacterial species<ref>PMID: 2268277</ref>.




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