Sandbox 177: Difference between revisions
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==='''Medical Significance'''=== | ==='''Medical Significance'''=== | ||
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Studies have shown that the reductase activity of CYPOR is capable of activating anticancer prodrugs.<ref name="5TSON"/> This makes it a potential target for anticancer research and therapy.<ref name=" | '''Cancer''' - Studies have shown that the reductase activity of CYPOR is capable of activating anticancer prodrugs.<ref name="5TSON"/><ref name="8TSON">PMID:2228151</ref> Elevated expression of CYPOR has been found to increase the sensitivity of cancerous cells to certain anticancer drugs like tirapazamine.<ref name="8TSON"/> This makes it a potential target for anticancer research and therapy. | ||
'''Embryology & Development''' - CYPOR is believed to play a key role in the spatial and temporal expression of various signaling factors that are key in establishing correct embryogenesis and development pathways.<ref name="9TSON">11742006</ref> In particular it appears that CYPOR is critical for embryos to progress into and past mid-gestation, as mice embryos lacking both CYPOR alleles did not survive past day 13.5 of gestation. <ref name="9TSON"/> Even heterozygotes for the allele were found to have a decreased survival rate after 2 weeks of gestation.<ref name="9TSON"/> | |||
==References== | ==References== | ||
