Sandbox 177: Difference between revisions

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'''Cancer''' - Studies have shown that the reductase activity of CYPOR is capable of activating anticancer prodrugs.<ref name="5TSON"/><ref name="8TSON">PMID:2228151</ref> Elevated expression of CYPOR has been found to increase the sensitivity of cancerous cells to certain anticancer drugs like tirapazamine.<ref name="8TSON"/> This makes it a potential target for anticancer research and therapy.

'''Embryology & Development''' - CYPOR is believed to play a key role in the spatial and temporal expression of various signaling factors that are key in establishing correct embryogenesis and development pathways.<ref name="9TSON">PMID:11742006</ref> Studies with mice have shown that CYPOR is critical for mice embryos to progress into and past mid-gestation, as embryos lacking both CYPOR alleles did not survive past day 13.5 of gestation. <ref name="9TSON"/> Even mice, who were heterozygotes for the allele, were found to have a decreased survival rate after 2 weeks of gestation.<ref name="9TSON"/> In humans, while deficiencies in CYPOR are not necessarily lethal, they do have some severe side effects, including disordered steroidogenesis and Antley-Bixler syndrome (ABS).<ref name="10aTSON/><ref name="10bTSON">PMID:16467261</ref> ABS is associated with urogenital defects (ie: ambiguous genitalia), cranial abnormalities (ie: brachycephaly) and skeletal defects (ie: bowed femurs, narrow ribcage and club feet), often due to disordered steroidogenesis.<ref name="10aTSON/><ref name="10bTSON/> Individuals with ABS and/or disordered steroidogenesis may have mutations in one or both alleles for CYPOR, although some cases are associated with mutations in another gene, fibroblast growth factor receptor 2 gene.<ref name="10bTSON/><ref name="10aTSON/>

'''Embryology & Development''' - CYPOR is believed to play a key role in the spatial and temporal expression of various signaling factors that are key in establishing correct embryogenesis and development pathways.<ref name="9TSON">PMID:11742006</ref> Studies with mice have shown that CYPOR is critical for mice embryos to progress into and past mid-gestation, as embryos lacking both CYPOR alleles did not survive past day 13.5 of gestation. <ref name="9TSON"/> Even mice, who were heterozygotes for the allele, were found to have a decreased survival rate after 2 weeks of gestation.<ref name="9TSON"/> In humans, while deficiencies in CYPOR are not necessarily lethal, they do have some severe side effects, including disordered steroidogenesis and Antley-Bixler syndrome (ABS).<ref name="10aTSON"/><ref name="10bTSON">PMID:16467261</ref> ABS is associated with urogenital defects (ie: ambiguous genitalia), cranial abnormalities (ie: brachycephaly) and skeletal defects (ie: bowed femurs, narrow ribcage and club feet), often due to disordered steroidogenesis.<ref name="10aTSON"/><ref name="10bTSON"/> Individuals with ABS and/or disordered steroidogenesis may have mutations in one or both alleles for CYPOR, although some cases are associated with mutations in another gene, fibroblast growth factor receptor 2 gene.<ref name="10bTSON"/><ref name="10aTSON"/>

Sandbox 177: Difference between revisions

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Revision as of 02:20, 29 March 2010 view source Taya O'Neill (talk \| contribs) 49 edits No edit summary ← Older edit		Revision as of 02:22, 29 March 2010 view source Taya O'Neill (talk \| contribs) 49 edits No edit summary Newer edit →
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	'''Cancer''' - Studies have shown that the reductase activity of CYPOR is capable of activating anticancer prodrugs.<ref name="5TSON"/><ref name="8TSON">PMID:2228151</ref> Elevated expression of CYPOR has been found to increase the sensitivity of cancerous cells to certain anticancer drugs like tirapazamine.<ref name="8TSON"/> This makes it a potential target for anticancer research and therapy.		'''Cancer''' - Studies have shown that the reductase activity of CYPOR is capable of activating anticancer prodrugs.<ref name="5TSON"/><ref name="8TSON">PMID:2228151</ref> Elevated expression of CYPOR has been found to increase the sensitivity of cancerous cells to certain anticancer drugs like tirapazamine.<ref name="8TSON"/> This makes it a potential target for anticancer research and therapy.

	'''Embryology & Development''' - CYPOR is believed to play a key role in the spatial and temporal expression of various signaling factors that are key in establishing correct embryogenesis and development pathways.<ref name="9TSON">PMID:11742006</ref> Studies with mice have shown that CYPOR is critical for mice embryos to progress into and past mid-gestation, as embryos lacking both CYPOR alleles did not survive past day 13.5 of gestation. <ref name="9TSON"/> Even mice, who were heterozygotes for the allele, were found to have a decreased survival rate after 2 weeks of gestation.<ref name="9TSON"/> In humans, while deficiencies in CYPOR are not necessarily lethal, they do have some severe side effects, including disordered steroidogenesis and Antley-Bixler syndrome (ABS).<ref name="10aTSON/><ref name="10bTSON">PMID:16467261</ref> ABS is associated with urogenital defects (ie: ambiguous genitalia), cranial abnormalities (ie: brachycephaly) and skeletal defects (ie: bowed femurs, narrow ribcage and club feet), often due to disordered steroidogenesis.<ref name="10aTSON/><ref name="10bTSON/> Individuals with ABS and/or disordered steroidogenesis may have mutations in one or both alleles for CYPOR, although some cases are associated with mutations in another gene, fibroblast growth factor receptor 2 gene.<ref name="10bTSON/><ref name="10aTSON/>		'''Embryology & Development''' - CYPOR is believed to play a key role in the spatial and temporal expression of various signaling factors that are key in establishing correct embryogenesis and development pathways.<ref name="9TSON">PMID:11742006</ref> Studies with mice have shown that CYPOR is critical for mice embryos to progress into and past mid-gestation, as embryos lacking both CYPOR alleles did not survive past day 13.5 of gestation. <ref name="9TSON"/> Even mice, who were heterozygotes for the allele, were found to have a decreased survival rate after 2 weeks of gestation.<ref name="9TSON"/> In humans, while deficiencies in CYPOR are not necessarily lethal, they do have some severe side effects, including disordered steroidogenesis and Antley-Bixler syndrome (ABS).<ref name="10aTSON"/><ref name="10bTSON">PMID:16467261</ref> ABS is associated with urogenital defects (ie: ambiguous genitalia), cranial abnormalities (ie: brachycephaly) and skeletal defects (ie: bowed femurs, narrow ribcage and club feet), often due to disordered steroidogenesis.<ref name="10aTSON"/><ref name="10bTSON"/> Individuals with ABS and/or disordered steroidogenesis may have mutations in one or both alleles for CYPOR, although some cases are associated with mutations in another gene, fibroblast growth factor receptor 2 gene.<ref name="10bTSON"/><ref name="10aTSON"/>