Sandbox 173: Difference between revisions
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====Recovery of the Pre-stimulus State==== | ====Recovery of the Pre-stimulus State==== | ||
In the event of a decrease in light intensity, GTP is hydrolyzed and the α-subunit of transducin reassociates with the βγ subunits, releasing the inhibitory subunit of phosphodiesterase. This subunit reassociates with phosphodiesterase and inhibits its activity<ref>Textbook</ref>. | In the event of a decrease in light intensity, GTP is hydrolyzed and the α-subunit of transducin reassociates with the βγ subunits, releasing the inhibitory subunit of phosphodiesterase. This subunit reassociates with phosphodiesterase and inhibits its activity<ref>Textbook</ref>. | ||
The concentration of cGMP is returned to the “dark” state by the conversion of GTP to cGMP by guanylyl cyclase, activated through the efflux of calcium ions through the sodium/calcium ion exchanger. The reduction | The concentration of cGMP is returned to the “dark” state by the conversion of GTP to cGMP by guanylyl cyclase, activated through the efflux of calcium ions through the sodium/calcium ion exchanger. The reduction in the concentration of calcium ions also inhibits phosphodiesterase activity. Both actions reopen the cation channels and restore the system to pre-stimulus state<ref>Textbook</ref>. | ||
====Phosphorylation and Deactivation of Rhodopsin==== | ====Phosphorylation and Deactivation of Rhodopsin==== | ||
